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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLRMT All Species: 20.3
Human Site: S666 Identified Species: 37.22
UniProt: O00411 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00411 NP_005026.3 1230 138620 S666 H S G A F L L S P T K L M R T
Chimpanzee Pan troglodytes XP_001172601 311 35421
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542220 1024 113870 A542 A E V R R E L A R C L K V A R
Cat Felis silvestris
Mouse Mus musculus Q8BKF1 1207 136686 S637 H S G A Y L L S S T K L M R A
Rat Rattus norvegicus NP_001100236 1203 135799 S635 H S G A Y L L S S T K I M R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001080987 1235 142073 S667 R F G A Y L L S P A K L M R C
Zebra Danio Brachydanio rerio XP_685138 1253 143135 T711 K S G A Y L L T P A K L M R A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608565 1369 156753 N793 H N G G Y L L N K T E L I R L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002311418 877 99587 A395 G L V D R E D A P L P E E P Q
Maize Zea mays NP_001104931 975 110846 V493 D L V D R T D V P V P E K P D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LFV6 1011 114502 V529 D M V D R S D V P L P E K P D
Baker's Yeast Sacchar. cerevisiae P13433 1351 153063 T693 R S G G Y H Y T Q S T L L R T
Red Bread Mold Neurospora crassa P38671 1423 159642 T648 E K G A Y L E T K T P V L R L
Conservation
Percent
Protein Identity: 100 23.4 N.A. 59.1 N.A. 66.9 65.6 N.A. N.A. N.A. 47.8 45.5 N.A. 37 N.A. N.A. N.A.
Protein Similarity: 100 24.2 N.A. 67.7 N.A. 78.2 77.9 N.A. N.A. N.A. 65 63.6 N.A. 55.2 N.A. N.A. N.A.
P-Site Identity: 100 0 N.A. 6.6 N.A. 80 73.3 N.A. N.A. N.A. 66.6 66.6 N.A. 46.6 N.A. N.A. N.A.
P-Site Similarity: 100 0 N.A. 20 N.A. 86.6 86.6 N.A. N.A. N.A. 73.3 80 N.A. 80 N.A. N.A. N.A.
Percent
Protein Identity: 30.7 30.8 N.A. 30 26.8 26.2
Protein Similarity: 44.1 46.9 N.A. 47.5 44.5 41.5
P-Site Identity: 6.6 6.6 N.A. 6.6 33.3 33.3
P-Site Similarity: 13.3 6.6 N.A. 6.6 60 60
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 47 0 0 0 16 0 16 0 0 0 8 24 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % C
% Asp: 16 0 0 24 0 0 24 0 0 0 0 0 0 0 16 % D
% Glu: 8 8 0 0 0 16 8 0 0 0 8 24 8 0 0 % E
% Phe: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 62 16 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 31 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 0 % I
% Lys: 8 8 0 0 0 0 0 0 16 0 39 8 16 0 0 % K
% Leu: 0 16 0 0 0 54 54 0 0 16 8 47 16 0 16 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 39 0 0 % M
% Asn: 0 8 0 0 0 0 0 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 47 0 31 0 0 24 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 8 % Q
% Arg: 16 0 0 8 31 0 0 0 8 0 0 0 0 62 8 % R
% Ser: 0 39 0 0 0 8 0 31 16 8 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 8 0 24 0 39 8 0 0 0 16 % T
% Val: 0 0 31 0 0 0 0 16 0 8 0 8 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 54 0 8 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _