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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLRMT All Species: 15.76
Human Site: S736 Identified Species: 28.89
UniProt: O00411 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00411 NP_005026.3 1230 138620 S736 L G V P A P P S E A P Q P P E
Chimpanzee Pan troglodytes XP_001172601 311 35421
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542220 1024 113870 H591 R T Y P C P P H F N H L G S D
Cat Felis silvestris
Mouse Mus musculus Q8BKF1 1207 136686 S707 L G V P P P R S E A P R P A R
Rat Rattus norvegicus NP_001100236 1203 135799 S705 L G V P P P R S E A P R P A K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001080987 1235 142073 S737 L D I P P P I S E A P K M P E
Zebra Danio Brachydanio rerio XP_685138 1253 143135 S781 L S I P P P L S E A P E I P R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608565 1369 156753 S863 L D V P Q P P S S L P P L P T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002311418 877 99587 K444 L A V A R K M K D E E G F Y Y
Maize Zea mays NP_001104931 975 110846 K542 L A V A R K M K D E E G F Y Y
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LFV6 1011 114502 K578 L S V A R K M K D E E A F Y Y
Baker's Yeast Sacchar. cerevisiae P13433 1351 153063 A760 G F L D I P G A Q D E M V L P
Red Bread Mold Neurospora crassa P38671 1423 159642 F720 I P P L D P I F D L P P E P A
Conservation
Percent
Protein Identity: 100 23.4 N.A. 59.1 N.A. 66.9 65.6 N.A. N.A. N.A. 47.8 45.5 N.A. 37 N.A. N.A. N.A.
Protein Similarity: 100 24.2 N.A. 67.7 N.A. 78.2 77.9 N.A. N.A. N.A. 65 63.6 N.A. 55.2 N.A. N.A. N.A.
P-Site Identity: 100 0 N.A. 20 N.A. 66.6 66.6 N.A. N.A. N.A. 60 53.3 N.A. 53.3 N.A. N.A. N.A.
P-Site Similarity: 100 0 N.A. 26.6 N.A. 73.3 80 N.A. N.A. N.A. 73.3 66.6 N.A. 53.3 N.A. N.A. N.A.
Percent
Protein Identity: 30.7 30.8 N.A. 30 26.8 26.2
Protein Similarity: 44.1 46.9 N.A. 47.5 44.5 41.5
P-Site Identity: 13.3 13.3 N.A. 13.3 6.6 20
P-Site Similarity: 20 20 N.A. 20 26.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 0 24 8 0 0 8 0 39 0 8 0 16 8 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 16 0 8 8 0 0 0 31 8 0 0 0 0 8 % D
% Glu: 0 0 0 0 0 0 0 0 39 24 31 8 8 0 16 % E
% Phe: 0 8 0 0 0 0 0 8 8 0 0 0 24 0 0 % F
% Gly: 8 24 0 0 0 0 8 0 0 0 0 16 8 0 0 % G
% His: 0 0 0 0 0 0 0 8 0 0 8 0 0 0 0 % H
% Ile: 8 0 16 0 8 0 16 0 0 0 0 0 8 0 0 % I
% Lys: 0 0 0 0 0 24 0 24 0 0 0 8 0 0 8 % K
% Leu: 70 0 8 8 0 0 8 0 0 16 0 8 8 8 0 % L
% Met: 0 0 0 0 0 0 24 0 0 0 0 8 8 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % N
% Pro: 0 8 8 54 31 70 24 0 0 0 54 16 24 39 8 % P
% Gln: 0 0 0 0 8 0 0 0 8 0 0 8 0 0 0 % Q
% Arg: 8 0 0 0 24 0 16 0 0 0 0 16 0 0 16 % R
% Ser: 0 16 0 0 0 0 0 47 8 0 0 0 0 8 0 % S
% Thr: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 8 % T
% Val: 0 0 54 0 0 0 0 0 0 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 0 0 0 0 24 24 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _