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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MANBA All Species: 20
Human Site: S733 Identified Species: 33.85
UniProt: O00462 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00462 NP_005899.3 879 100895 S733 S S L E P V C S R V T E R F V
Chimpanzee Pan troglodytes XP_517370 879 100802 S733 S S L E P M C S H V T E H F V
Rhesus Macaque Macaca mulatta XP_001101549 1074 122458 S928 S S L E P V C S C V T E H L V
Dog Lupus familis XP_545005 885 101736 S739 S S L E P L C S S E T E Y F V
Cat Felis silvestris
Mouse Mus musculus Q8K2I4 879 100812 S733 S S P K P L C S L V N S S I V
Rat Rattus norvegicus Q4FZV0 881 101203 T733 S S Q K P L C T F V S L S A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_420666 822 94668 L677 S L E P V C T L V K D G V T V
Frog Xenopus laevis NP_001087135 874 101196 C728 W N S Q V P V C E Q L T E E L
Zebra Danio Brachydanio rerio XP_002664183 901 102422 S753 S S F N P V C S L E S N M T T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649436 908 103501 L750 V H L W S Q L L P R Q S T S W
Honey Bee Apis mellifera XP_392850 1110 128827 T964 T Y P I K N V T L E M N L Y T
Nematode Worm Caenorhab. elegans Q93324 900 103960 P754 S W G N G L D P I L T N E F H
Sea Urchin Strong. purpuratus XP_001186463 724 81612 W579 P V S I A T D W S Y T S T F S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q75W54 944 107642 E792 G K N Y T L L E P Y R K K Q I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 76.5 80.4 N.A. 75.7 75.2 N.A. N.A. 64.2 58.1 53.8 N.A. 34.6 29.9 33.3 39.2
Protein Similarity: 100 99.5 79.2 87.6 N.A. 85.8 86.6 N.A. N.A. 77.5 74.2 70.4 N.A. 52.2 47.2 54.1 52.3
P-Site Identity: 100 80 80 73.3 N.A. 46.6 40 N.A. N.A. 13.3 0 40 N.A. 6.6 0 20 13.3
P-Site Similarity: 100 86.6 80 80 N.A. 60 66.6 N.A. N.A. 13.3 20 46.6 N.A. 6.6 20 33.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. 21 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 39.1 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 8 50 8 8 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 15 0 0 0 8 0 0 0 0 % D
% Glu: 0 0 8 29 0 0 0 8 8 22 0 29 15 8 0 % E
% Phe: 0 0 8 0 0 0 0 0 8 0 0 0 0 36 0 % F
% Gly: 8 0 8 0 8 0 0 0 0 0 0 8 0 0 0 % G
% His: 0 8 0 0 0 0 0 0 8 0 0 0 15 0 8 % H
% Ile: 0 0 0 15 0 0 0 0 8 0 0 0 0 8 8 % I
% Lys: 0 8 0 15 8 0 0 0 0 8 0 8 8 0 0 % K
% Leu: 0 8 36 0 0 36 15 15 22 8 8 8 8 8 8 % L
% Met: 0 0 0 0 0 8 0 0 0 0 8 0 8 0 0 % M
% Asn: 0 8 8 15 0 8 0 0 0 0 8 22 0 0 0 % N
% Pro: 8 0 15 8 50 8 0 8 15 0 0 0 0 0 0 % P
% Gln: 0 0 8 8 0 8 0 0 0 8 8 0 0 8 0 % Q
% Arg: 0 0 0 0 0 0 0 0 8 8 8 0 8 0 0 % R
% Ser: 65 50 15 0 8 0 0 43 15 0 15 22 15 8 8 % S
% Thr: 8 0 0 0 8 8 8 15 0 0 43 8 15 15 15 % T
% Val: 8 8 0 0 15 22 15 0 8 36 0 0 8 0 50 % V
% Trp: 8 8 0 8 0 0 0 8 0 0 0 0 0 0 8 % W
% Tyr: 0 8 0 8 0 0 0 0 0 15 0 0 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _