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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BIN1
All Species:
13.94
Human Site:
S432
Identified Species:
38.33
UniProt:
O00499
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00499
NP_004296.1
593
64699
S432
S
P
A
G
S
L
P
S
G
E
P
S
A
A
E
Chimpanzee
Pan troglodytes
XP_001136718
592
64201
S431
S
P
A
G
S
L
P
S
G
E
P
S
A
A
E
Rhesus Macaque
Macaca mulatta
XP_001102998
517
56941
Y386
A
C
M
A
F
I
L
Y
A
S
V
S
R
A
K
Dog
Lupus familis
XP_540990
695
75918
P534
S
P
A
G
S
L
P
P
G
E
P
S
A
T
E
Cat
Felis silvestris
Mouse
Mus musculus
O08539
588
64452
S433
S
Q
A
G
I
L
P
S
G
E
P
S
S
A
E
Rat
Rattus norvegicus
O08839
588
64515
S433
S
Q
A
G
V
L
P
S
G
E
P
S
S
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516781
684
75094
L415
P
S
M
P
T
T
S
L
Q
S
R
E
L
V
S
Chicken
Gallus gallus
P50478
682
75187
E519
E
G
D
K
P
Q
G
E
E
K
D
V
D
V
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001921434
530
59124
D398
A
D
D
D
K
E
D
D
G
S
Q
P
V
Q
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.2
64.7
81.4
N.A.
94.7
94.4
N.A.
35.8
35.4
N.A.
50
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
95.9
69.1
82.7
N.A.
96.6
96.4
N.A.
49.1
50.1
N.A.
65.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
13.3
86.6
N.A.
80
80
N.A.
0
0
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
33.3
86.6
N.A.
86.6
86.6
N.A.
6.6
6.6
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
23
0
56
12
0
0
0
0
12
0
0
0
34
56
12
% A
% Cys:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
12
23
12
0
0
12
12
0
0
12
0
12
0
0
% D
% Glu:
12
0
0
0
0
12
0
12
12
56
0
12
0
0
56
% E
% Phe:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
12
0
56
0
0
12
0
67
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
12
12
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
12
12
0
0
0
0
12
0
0
0
0
12
% K
% Leu:
0
0
0
0
0
56
12
12
0
0
0
0
12
0
0
% L
% Met:
0
0
23
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
12
34
0
12
12
0
56
12
0
0
56
12
0
0
0
% P
% Gln:
0
23
0
0
0
12
0
0
12
0
12
0
0
12
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
12
0
12
0
0
% R
% Ser:
56
12
0
0
34
0
12
45
0
34
0
67
23
0
23
% S
% Thr:
0
0
0
0
12
12
0
0
0
0
0
0
0
12
0
% T
% Val:
0
0
0
0
12
0
0
0
0
0
12
12
12
23
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _