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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PES1
All Species:
12.73
Human Site:
S457
Identified Species:
20
UniProt:
O00541
Number Species:
14
Phosphosite Substitution
Charge Score:
0.43
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00541
NP_055118.1
588
68003
S457
D
P
G
N
L
N
E
S
E
E
E
E
E
E
D
Chimpanzee
Pan troglodytes
XP_001143647
588
67990
S457
D
P
G
N
L
N
E
S
E
E
E
E
E
E
D
Rhesus Macaque
Macaca mulatta
XP_001110399
679
77752
S548
D
P
G
N
L
N
E
S
E
E
E
E
E
E
D
Dog
Lupus familis
XP_543480
584
67748
S456
H
P
G
N
T
D
E
S
E
E
E
D
E
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQ61
584
67777
E456
D
P
G
H
L
E
E
E
E
E
E
D
E
D
D
Rat
Rattus norvegicus
Q3B8N8
586
67586
E456
D
P
G
N
L
E
E
E
E
E
D
E
D
D
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508188
378
43758
Q294
V
M
E
E
Q
R
S
Q
G
K
T
P
K
V
T
Chicken
Gallus gallus
XP_001234133
524
60851
E436
L
L
A
M
Q
R
G
E
D
P
G
D
A
L
P
Frog
Xenopus laevis
Q7ZY69
574
67098
E457
E
N
L
G
L
D
E
E
D
D
D
D
D
D
D
Zebra Danio
Brachydanio rerio
P79741
583
67880
A454
Q
R
G
E
K
P
Q
A
E
E
D
E
E
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VL96
627
73844
A461
D
D
D
S
E
D
E
A
Q
E
E
E
E
T
V
Honey Bee
Apis mellifera
XP_001119862
555
66223
N451
D
P
E
F
K
L
N
N
E
D
E
S
E
E
E
Nematode Worm
Caenorhab. elegans
Q95Y89
531
61607
D432
E
L
R
S
M
G
K
D
V
S
D
L
E
A
A
Sea Urchin
Strong. purpuratus
XP_001200338
596
69851
D484
E
E
G
L
S
S
D
D
D
E
E
E
E
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SFC2
663
75275
A539
N
D
M
D
V
D
E
A
E
D
D
E
E
E
E
Conservation
Percent
Protein Identity:
100
99.3
83
90.3
N.A.
89.4
89.4
N.A.
47.4
72.6
71.4
73.9
N.A.
43.2
46
42.6
49.6
Protein Similarity:
100
99.4
85.1
94.3
N.A.
93.8
94
N.A.
55.6
80.2
86.2
84
N.A.
60.7
62.5
58.5
66.6
P-Site Identity:
100
100
100
66.6
N.A.
66.6
60
N.A.
0
0
20
40
N.A.
40
40
6.6
46.6
P-Site Similarity:
100
100
100
80
N.A.
86.6
86.6
N.A.
13.3
13.3
73.3
66.6
N.A.
66.6
60
40
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
40.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
55.6
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
86.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
0
20
0
0
0
0
7
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
14
7
7
0
27
7
14
20
20
34
27
14
20
40
% D
% Glu:
20
7
14
14
7
14
60
27
60
60
54
54
74
54
27
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
54
7
0
7
7
0
7
0
7
0
0
0
7
% G
% His:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
14
0
7
0
0
7
0
0
7
0
0
% K
% Leu:
7
14
7
7
40
7
0
0
0
0
0
7
0
7
0
% L
% Met:
0
7
7
7
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
7
0
34
0
20
7
7
0
0
0
0
0
0
0
% N
% Pro:
0
47
0
0
0
7
0
0
0
7
0
7
0
0
7
% P
% Gln:
7
0
0
0
14
0
7
7
7
0
0
0
0
0
0
% Q
% Arg:
0
7
7
0
0
14
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
14
7
7
7
27
0
7
0
7
0
0
0
% S
% Thr:
0
0
0
0
7
0
0
0
0
0
7
0
0
7
7
% T
% Val:
7
0
0
0
7
0
0
0
7
0
0
0
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _