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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PES1 All Species: 37.58
Human Site: T63 Identified Species: 59.05
UniProt: O00541 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00541 NP_055118.1 588 68003 T63 K G S T A A R T F Y L I K D I
Chimpanzee Pan troglodytes XP_001143647 588 67990 T63 K G S T A A R T F Y L I K D I
Rhesus Macaque Macaca mulatta XP_001110399 679 77752 T154 K G S T A A R T F Y L I K D I
Dog Lupus familis XP_543480 584 67748 T63 K G S T A A R T F Y L L K D I
Cat Felis silvestris
Mouse Mus musculus Q9EQ61 584 67777 T63 K G S T A A R T F Y L I K D I
Rat Rattus norvegicus Q3B8N8 586 67586 T63 K G S T A A R T F Y L I K D I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508188 378 43758
Chicken Gallus gallus XP_001234133 524 60851 L60 T A A R T F Y L L K D I K F L
Frog Xenopus laevis Q7ZY69 574 67098 T63 K G S T A P R T F Y L L K D I
Zebra Danio Brachydanio rerio P79741 583 67880 T63 K G S T A A R T Y Y L L K D I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VL96 627 73844 V61 K G S S E I K V L Y H T K D I
Honey Bee Apis mellifera XP_001119862 555 66223 I63 K G D P S I K I L Y H K K D I
Nematode Worm Caenorhab. elegans Q95Y89 531 61607 V63 K G S T A N K V F Y Y R K D I
Sea Urchin Strong. purpuratus XP_001200338 596 69851 T62 K G Q R L H R T Y F R F K D I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SFC2 663 75275 T62 K S A T A S T T F Y Y T K D I
Conservation
Percent
Protein Identity: 100 99.3 83 90.3 N.A. 89.4 89.4 N.A. 47.4 72.6 71.4 73.9 N.A. 43.2 46 42.6 49.6
Protein Similarity: 100 99.4 85.1 94.3 N.A. 93.8 94 N.A. 55.6 80.2 86.2 84 N.A. 60.7 62.5 58.5 66.6
P-Site Identity: 100 100 100 93.3 N.A. 100 100 N.A. 0 13.3 86.6 86.6 N.A. 46.6 40 66.6 46.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 0 26.6 93.3 100 N.A. 60 53.3 73.3 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 40.1
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 55.6
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 60
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 73.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 14 0 67 47 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 0 0 0 0 0 0 7 0 0 87 0 % D
% Glu: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 7 0 0 60 7 0 7 0 7 0 % F
% Gly: 0 80 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 7 0 0 0 0 14 0 0 0 0 % H
% Ile: 0 0 0 0 0 14 0 7 0 0 0 40 0 0 87 % I
% Lys: 87 0 0 0 0 0 20 0 0 7 0 7 94 0 0 % K
% Leu: 0 0 0 0 7 0 0 7 20 0 54 20 0 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 7 0 7 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 14 0 0 60 0 0 0 7 7 0 0 0 % R
% Ser: 0 7 67 7 7 7 0 0 0 0 0 0 0 0 0 % S
% Thr: 7 0 0 67 7 0 7 67 0 0 0 14 0 0 0 % T
% Val: 0 0 0 0 0 0 0 14 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 7 0 14 80 14 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _