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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PES1
All Species:
24.55
Human Site:
Y265
Identified Species:
38.57
UniProt:
O00541
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00541
NP_055118.1
588
68003
Y265
A
K
A
G
E
G
T
Y
A
L
D
S
E
S
C
Chimpanzee
Pan troglodytes
XP_001143647
588
67990
Y265
A
K
A
S
E
G
T
Y
A
L
D
S
E
S
S
Rhesus Macaque
Macaca mulatta
XP_001110399
679
77752
Y356
A
K
A
S
E
G
T
Y
A
L
D
S
E
S
S
Dog
Lupus familis
XP_543480
584
67748
Y265
A
K
T
S
E
D
T
Y
A
L
D
S
E
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQ61
584
67777
Y265
T
K
I
S
E
D
T
Y
A
L
D
S
E
S
S
Rat
Rattus norvegicus
Q3B8N8
586
67586
Y265
M
K
V
S
E
D
T
Y
A
L
D
S
E
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508188
378
43758
I137
R
E
A
L
A
F
I
I
R
S
F
G
G
E
V
Chicken
Gallus gallus
XP_001234133
524
60851
Y260
K
P
A
E
G
K
E
Y
A
M
D
S
E
S
Y
Frog
Xenopus laevis
Q7ZY69
574
67098
Y266
K
S
D
G
E
D
K
Y
A
L
E
T
E
V
Y
Zebra Danio
Brachydanio rerio
P79741
583
67880
Y266
K
A
E
F
E
E
D
Y
A
L
E
S
E
S
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VL96
627
73844
L262
L
Q
D
S
E
E
S
L
K
D
E
A
S
F
V
Honey Bee
Apis mellifera
XP_001119862
555
66223
E265
S
E
K
I
L
V
D
E
E
V
Y
V
S
E
R
Nematode Worm
Caenorhab. elegans
Q95Y89
531
61607
V268
T
E
E
Y
K
E
K
V
Y
S
L
A
K
P
L
Sea Urchin
Strong. purpuratus
XP_001200338
596
69851
V265
S
E
A
E
Q
D
E
V
D
D
A
V
D
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SFC2
663
75275
L273
A
E
L
G
A
F
S
L
E
G
V
N
M
A
T
Conservation
Percent
Protein Identity:
100
99.3
83
90.3
N.A.
89.4
89.4
N.A.
47.4
72.6
71.4
73.9
N.A.
43.2
46
42.6
49.6
Protein Similarity:
100
99.4
85.1
94.3
N.A.
93.8
94
N.A.
55.6
80.2
86.2
84
N.A.
60.7
62.5
58.5
66.6
P-Site Identity:
100
86.6
86.6
73.3
N.A.
66.6
66.6
N.A.
6.6
46.6
40
46.6
N.A.
6.6
0
0
6.6
P-Site Similarity:
100
86.6
86.6
73.3
N.A.
66.6
66.6
N.A.
13.3
53.3
53.3
53.3
N.A.
33.3
20
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
40.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
55.6
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
7
40
0
14
0
0
0
60
0
7
14
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
0
14
0
0
34
14
0
7
14
47
0
7
7
0
% D
% Glu:
0
34
14
14
60
20
14
7
14
0
20
0
60
14
0
% E
% Phe:
0
0
0
7
0
14
0
0
0
0
7
0
0
7
0
% F
% Gly:
0
0
0
20
7
20
0
0
0
7
0
7
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
7
0
0
7
7
0
0
0
0
0
0
0
% I
% Lys:
20
40
7
0
7
7
14
0
7
0
0
0
7
0
0
% K
% Leu:
7
0
7
7
7
0
0
14
0
54
7
0
0
0
14
% L
% Met:
7
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
7
0
0
0
0
0
0
0
0
0
0
0
7
0
% P
% Gln:
0
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
0
0
0
0
0
0
7
0
0
0
0
0
7
% R
% Ser:
14
7
0
40
0
0
14
0
0
14
0
54
14
54
34
% S
% Thr:
14
0
7
0
0
0
40
0
0
0
0
7
0
0
7
% T
% Val:
0
0
7
0
0
7
0
14
0
7
7
14
0
7
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
60
7
0
7
0
0
0
20
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _