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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PES1 All Species: 34.85
Human Site: Y96 Identified Species: 54.76
UniProt: O00541 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00541 NP_055118.1 588 68003 Y96 V R K L R K A Y G K S E W N T
Chimpanzee Pan troglodytes XP_001143647 588 67990 Y96 V R K L R K A Y G K S E W N T
Rhesus Macaque Macaca mulatta XP_001110399 679 77752 Y187 V R K L R K A Y G K S E W N T
Dog Lupus familis XP_543480 584 67748 Y96 V R K L R K A Y G K S E W N T
Cat Felis silvestris
Mouse Mus musculus Q9EQ61 584 67777 Y96 V R K L R K A Y G K S E W N A
Rat Rattus norvegicus Q3B8N8 586 67586 Y96 V R K L R K A Y G K S E W N A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508188 378 43758
Chicken Gallus gallus XP_001234133 524 60851 Y90 V R K L R K A Y G K S E W G T
Frog Xenopus laevis Q7ZY69 574 67098 Y96 V R R L R K A Y G K R E W D S
Zebra Danio Brachydanio rerio P79741 583 67880 Y96 V R K L R K A Y G K A E W S A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VL96 627 73844 R94 A K K S N R D R A I K D F R N
Honey Bee Apis mellifera XP_001119862 555 66223 R96 N K K V G R A R A L R E F S D
Nematode Worm Caenorhab. elegans Q95Y89 531 61607 K96 L R K L N H L K A K K E E D K
Sea Urchin Strong. purpuratus XP_001200338 596 69851 K95 V R K V R K A K A K K E W A T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SFC2 663 75275 A103 G R G D V S D A A R F E R H A
Conservation
Percent
Protein Identity: 100 99.3 83 90.3 N.A. 89.4 89.4 N.A. 47.4 72.6 71.4 73.9 N.A. 43.2 46 42.6 49.6
Protein Similarity: 100 99.4 85.1 94.3 N.A. 93.8 94 N.A. 55.6 80.2 86.2 84 N.A. 60.7 62.5 58.5 66.6
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 0 93.3 73.3 80 N.A. 6.6 20 33.3 66.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 0 93.3 93.3 93.3 N.A. 33.3 53.3 46.6 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 40.1
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 55.6
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 74 7 34 0 7 0 0 7 27 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 0 14 0 0 0 0 7 0 14 7 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 87 7 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 7 0 14 0 0 % F
% Gly: 7 0 7 0 7 0 0 0 60 0 0 0 0 7 0 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % I
% Lys: 0 14 80 0 0 67 0 14 0 74 20 0 0 0 7 % K
% Leu: 7 0 0 67 0 0 7 0 0 7 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 14 0 0 0 0 0 0 0 0 40 7 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 80 7 0 67 14 0 14 0 7 14 0 7 7 0 % R
% Ser: 0 0 0 7 0 7 0 0 0 0 47 0 0 14 7 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 40 % T
% Val: 67 0 0 14 7 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 67 0 0 % W
% Tyr: 0 0 0 0 0 0 0 60 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _