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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DLL1
All Species:
11.21
Human Site:
Y641
Identified Species:
20.56
UniProt:
O00548
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00548
NP_005609.3
723
78056
Y641
A
R
Y
P
A
V
D
Y
N
L
V
Q
D
L
K
Chimpanzee
Pan troglodytes
XP_510318
685
74575
S603
V
D
C
G
L
D
K
S
N
C
G
K
Q
Q
N
Rhesus Macaque
Macaca mulatta
XP_001099250
685
74578
S603
V
D
C
G
L
D
K
S
N
C
G
K
Q
Q
N
Dog
Lupus familis
XP_849154
685
74341
S603
V
D
C
G
L
D
K
S
N
C
G
K
Q
Q
N
Cat
Felis silvestris
Mouse
Mus musculus
Q61483
722
78430
Y641
V
R
Y
P
T
V
D
Y
N
L
V
R
D
L
K
Rat
Rattus norvegicus
P97677
714
77360
Y633
A
R
Y
P
T
V
D
Y
N
L
I
R
D
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518138
509
54239
E428
V
P
D
L
K
S
A
E
R
G
G
E
D
L
G
Chicken
Gallus gallus
NP_990304
728
79843
V646
Y
K
V
R
Y
P
S
V
D
Y
N
L
V
H
E
Frog
Xenopus laevis
NP_001079551
642
70637
K560
V
N
N
D
L
E
P
K
N
N
L
I
E
K
E
Zebra Danio
Brachydanio rerio
Q8UWJ4
717
79043
Y635
K
N
G
F
K
S
R
Y
S
L
V
D
Y
N
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P10041
833
88822
K739
V
A
P
L
Q
R
A
K
S
Q
K
Q
L
N
T
Honey Bee
Apis mellifera
XP_393831
1119
119736
A1001
Y
K
P
E
P
V
L
A
D
G
R
T
R
T
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P10079
1064
112055
G965
T
S
T
G
M
M
L
G
D
Y
M
T
Y
N
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
50.9
51
51
N.A.
88.5
88.5
N.A.
56.5
83.6
48.9
70.4
N.A.
37.3
31.8
N.A.
23.9
Protein Similarity:
100
64.5
64.3
63.4
N.A.
94.4
93.6
N.A.
60.5
90.1
62.5
82.5
N.A.
50.1
41
N.A.
34.9
P-Site Identity:
100
6.6
6.6
6.6
N.A.
80
80
N.A.
13.3
0
6.6
20
N.A.
6.6
6.6
N.A.
0
P-Site Similarity:
100
13.3
13.3
13.3
N.A.
86.6
93.3
N.A.
20
20
26.6
26.6
N.A.
13.3
20
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
0
0
8
0
16
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
24
0
0
0
0
0
0
24
0
0
0
0
0
% C
% Asp:
0
24
8
8
0
24
24
0
24
0
0
8
31
0
0
% D
% Glu:
0
0
0
8
0
8
0
8
0
0
0
8
8
0
24
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
31
0
0
0
8
0
16
31
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% I
% Lys:
8
16
0
0
16
0
24
16
0
0
8
24
0
8
24
% K
% Leu:
0
0
0
16
31
0
16
0
0
31
8
8
8
31
8
% L
% Met:
0
0
0
0
8
8
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
16
8
0
0
0
0
0
54
8
8
0
0
24
24
% N
% Pro:
0
8
16
24
8
8
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
8
0
16
24
24
0
% Q
% Arg:
0
24
0
8
0
8
8
0
8
0
8
16
8
0
0
% R
% Ser:
0
8
0
0
0
16
8
24
16
0
0
0
0
0
0
% S
% Thr:
8
0
8
0
16
0
0
0
0
0
0
16
0
8
16
% T
% Val:
54
0
8
0
0
31
0
8
0
0
24
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
0
24
0
8
0
0
31
0
16
0
0
16
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _