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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CACNA1A All Species: 3.64
Human Site: S2247 Identified Species: 8
UniProt: O00555 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00555 NP_001120693.1 2505 282365 S2247 R A R D Q R W S R S P S E G R
Chimpanzee Pan troglodytes XP_520396 2784 310342 P2536 A A G P G L P P G E G P T G C
Rhesus Macaque Macaca mulatta XP_001110352 2383 269535 S2116 E S P E R R Q S R S P S E G R
Dog Lupus familis XP_537779 2046 229120 P1798 S S A A G P G P P L G E G P A
Cat Felis silvestris
Mouse Mus musculus P97445 2368 267629 L2119 H R T S E R S L G R Y T D V D
Rat Rattus norvegicus P54282 2212 251509 D1964 A L P S T Q L D P G G G L M A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus O73700 2190 249326 P1942 P R R R L L P P T P A S N R R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_690548 2303 262065 D2052 R S L S R Y T D A D T G L G T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91645 1851 212452 G1603 S H P R Y P R G S W S A S T S
Honey Bee Apis mellifera NP_001159376 1904 215872 K1656 E S L T H T G K R L H P P V Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001186699 1966 222605 D1718 R A P I S T R D V S P Q R F P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 55 55.9 54.6 N.A. 87.9 82.7 N.A. N.A. 35.9 N.A. 72.3 N.A. 43 44.4 N.A. 39.6
Protein Similarity: 100 63.5 66.3 63.4 N.A. 89.9 84.6 N.A. N.A. 50.4 N.A. 80 N.A. 53.9 55.4 N.A. 51.6
P-Site Identity: 100 13.3 60 0 N.A. 6.6 0 N.A. N.A. 20 N.A. 13.3 N.A. 0 6.6 N.A. 26.6
P-Site Similarity: 100 13.3 80 6.6 N.A. 26.6 6.6 N.A. N.A. 20 N.A. 26.6 N.A. 6.6 20 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 28 10 10 0 0 0 0 10 0 10 10 0 0 19 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 0 0 0 10 0 0 0 28 0 10 0 0 10 0 10 % D
% Glu: 19 0 0 10 10 0 0 0 0 10 0 10 19 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % F
% Gly: 0 0 10 0 19 0 19 10 19 10 28 19 10 37 0 % G
% His: 10 10 0 0 10 0 0 0 0 0 10 0 0 0 0 % H
% Ile: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % K
% Leu: 0 10 19 0 10 19 10 10 0 19 0 0 19 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % N
% Pro: 10 0 37 10 0 19 19 28 19 10 28 19 10 10 10 % P
% Gln: 0 0 0 0 10 10 10 0 0 0 0 10 0 0 10 % Q
% Arg: 28 19 19 19 19 28 19 0 28 10 0 0 10 10 28 % R
% Ser: 19 37 0 28 10 0 10 19 10 28 10 28 10 0 10 % S
% Thr: 0 0 10 10 10 19 10 0 10 0 10 10 10 10 10 % T
% Val: 0 0 0 0 0 0 0 0 10 0 0 0 0 19 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 10 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 10 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _