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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CACNA1A All Species: 2.73
Human Site: S2359 Identified Species: 6
UniProt: O00555 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00555 NP_001120693.1 2505 282365 S2359 R P P T G G H S S G R S P R M
Chimpanzee Pan troglodytes XP_520396 2784 310342 P2639 R R Q L P Q T P L T P R P S I
Rhesus Macaque Macaca mulatta XP_001110352 2383 269535 D2235 P Y L A L H E D S H A S D C G
Dog Lupus familis XP_537779 2046 229120 P1901 R R Q L P Q T P L T P R P S V
Cat Felis silvestris
Mouse Mus musculus P97445 2368 267629 A2222 S S V S G S P A P S T S G T S
Rat Rattus norvegicus P54282 2212 251509 I2067 R G N N L S T I S D T S P M K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus O73700 2190 249326 L2045 T E H M N G S L P S L H R S S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_690548 2303 262065 T2156 S G S P V P S T S G T S T P R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91645 1851 212452 P1706 P S T L Q L K P T N I N F P K
Honey Bee Apis mellifera NP_001159376 1904 215872 S1759 T T S L E Q R S R S P S P I G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001186699 1966 222605 T1821 H T G R R L P T V P G E T R G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 55 55.9 54.6 N.A. 87.9 82.7 N.A. N.A. 35.9 N.A. 72.3 N.A. 43 44.4 N.A. 39.6
Protein Similarity: 100 63.5 66.3 63.4 N.A. 89.9 84.6 N.A. N.A. 50.4 N.A. 80 N.A. 53.9 55.4 N.A. 51.6
P-Site Identity: 100 13.3 13.3 13.3 N.A. 13.3 26.6 N.A. N.A. 6.6 N.A. 20 N.A. 0 20 N.A. 6.6
P-Site Similarity: 100 20 13.3 20 N.A. 26.6 26.6 N.A. N.A. 6.6 N.A. 26.6 N.A. 13.3 20 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 0 0 10 0 0 10 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 0 0 0 0 0 0 0 10 0 10 0 0 10 0 0 % D
% Glu: 0 10 0 0 10 0 10 0 0 0 0 10 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 0 19 10 0 19 19 0 0 0 19 10 0 10 0 28 % G
% His: 10 0 10 0 0 10 10 0 0 10 0 10 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 10 0 0 10 0 0 10 10 % I
% Lys: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 19 % K
% Leu: 0 0 10 37 19 19 0 10 19 0 10 0 0 0 0 % L
% Met: 0 0 0 10 0 0 0 0 0 0 0 0 0 10 10 % M
% Asn: 0 0 10 10 10 0 0 0 0 10 0 10 0 0 0 % N
% Pro: 19 10 10 10 19 10 19 28 19 10 28 0 46 19 0 % P
% Gln: 0 0 19 0 10 28 0 0 0 0 0 0 0 0 0 % Q
% Arg: 37 19 0 10 10 0 10 0 10 0 10 19 10 19 10 % R
% Ser: 19 19 19 10 0 19 19 19 37 28 0 55 0 28 19 % S
% Thr: 19 19 10 10 0 0 28 19 10 19 28 0 19 10 0 % T
% Val: 0 0 10 0 10 0 0 0 10 0 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _