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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PEX12 All Species: 15.45
Human Site: S219 Identified Species: 22.67
UniProt: O00623 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00623 NP_000277.1 359 40797 S219 E H K P A K A S M M Q Q P A R
Chimpanzee Pan troglodytes XP_001174172 359 40821 S219 E H K P A K A S M M Q R P A R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_548259 359 40831 S219 E H K P A E A S M M Q Q P A R
Cat Felis silvestris
Mouse Mus musculus Q8VC48 359 40614 S219 K Q R L V E A S A M Q E P V R
Rat Rattus norvegicus O88177 359 40663 S219 E H R L V E A S A M Q E P V R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511496 312 33803 W173 A H L A W E G W F L G Q Q L C
Chicken Gallus gallus XP_415773 356 39947 V216 A L E K K L A V A A S S Q T H
Frog Xenopus laevis NP_001086511 353 40718 N214 E K Q E E L T N T V S N V V S
Zebra Danio Brachydanio rerio NP_956499 303 34092 M164 A A Y P F V C M A W D G W V F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VPT5 297 34525 Y158 T F F Y L V K Y A S N H S P I
Honey Bee Apis mellifera XP_624974 285 32991 I146 L L L R L L S I T L T Y A E P
Nematode Worm Caenorhab. elegans Q19189 359 41271 Q218 N A V P L H L Q T G Y Q I S R
Sea Urchin Strong. purpuratus XP_788130 354 40571 D214 M L L G L S S D A I L S A D S
Poplar Tree Populus trichocarpa XP_002325774 388 43941 N249 R I S K I R S N E R E R L H G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M841 393 44382 H254 R I S K I R N H E R E R L R G
Baker's Yeast Sacchar. cerevisiae Q04370 399 45974 R249 K G M D N R L R K T N I S S I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 N.A. 92.1 N.A. 89.4 88.5 N.A. 46.7 76 64 51.5 N.A. 29.8 31.7 35.9 45.6
Protein Similarity: 100 99.7 N.A. 96 N.A. 93.3 92.7 N.A. 57.3 85.7 79.6 65.4 N.A. 47 49 56.2 68.5
P-Site Identity: 100 93.3 N.A. 93.3 N.A. 40 53.3 N.A. 13.3 6.6 6.6 6.6 N.A. 0 0 20 0
P-Site Similarity: 100 100 N.A. 100 N.A. 66.6 73.3 N.A. 26.6 13.3 26.6 6.6 N.A. 0 13.3 26.6 13.3
Percent
Protein Identity: 31.9 N.A. N.A. 31.3 22.3 N.A.
Protein Similarity: 48.7 N.A. N.A. 48.3 40.3 N.A.
P-Site Identity: 0 N.A. N.A. 0 0 N.A.
P-Site Similarity: 33.3 N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 13 0 7 19 0 38 0 38 7 0 0 13 19 0 % A
% Cys: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 7 % C
% Asp: 0 0 0 7 0 0 0 7 0 0 7 0 0 7 0 % D
% Glu: 32 0 7 7 7 25 0 0 13 0 13 13 0 7 0 % E
% Phe: 0 7 7 0 7 0 0 0 7 0 0 0 0 0 7 % F
% Gly: 0 7 0 7 0 0 7 0 0 7 7 7 0 0 13 % G
% His: 0 32 0 0 0 7 0 7 0 0 0 7 0 7 7 % H
% Ile: 0 13 0 0 13 0 0 7 0 7 0 7 7 0 13 % I
% Lys: 13 7 19 19 7 13 7 0 7 0 0 0 0 0 0 % K
% Leu: 7 19 19 13 25 19 13 0 0 13 7 0 13 7 0 % L
% Met: 7 0 7 0 0 0 0 7 19 32 0 0 0 0 0 % M
% Asn: 7 0 0 0 7 0 7 13 0 0 13 7 0 0 0 % N
% Pro: 0 0 0 32 0 0 0 0 0 0 0 0 32 7 7 % P
% Gln: 0 7 7 0 0 0 0 7 0 0 32 25 13 0 0 % Q
% Arg: 13 0 13 7 0 19 0 7 0 13 0 19 0 7 38 % R
% Ser: 0 0 13 0 0 7 19 32 0 7 13 13 13 13 13 % S
% Thr: 7 0 0 0 0 0 7 0 19 7 7 0 0 7 0 % T
% Val: 0 0 7 0 13 13 0 7 0 7 0 0 7 25 0 % V
% Trp: 0 0 0 0 7 0 0 7 0 7 0 0 7 0 0 % W
% Tyr: 0 0 7 7 0 0 0 7 0 0 7 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _