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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PEX12 All Species: 23.94
Human Site: T281 Identified Species: 35.11
UniProt: O00623 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00623 NP_000277.1 359 40797 T281 K S L T A L P T P P P P V H L
Chimpanzee Pan troglodytes XP_001174172 359 40821 T281 K S L T A L P T P P P P V H L
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_548259 359 40831 T281 K S L T A L P T P P P P V H L
Cat Felis silvestris
Mouse Mus musculus Q8VC48 359 40614 T281 K S L T A L P T P P P P V H L
Rat Rattus norvegicus O88177 359 40663 T281 K S L T A L P T P P P P V H L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511496 312 33803 R235 T G G E T M S R Y W L V F L P
Chicken Gallus gallus XP_415773 356 39947 T278 K S L T A L P T P P P P V H L
Frog Xenopus laevis NP_001086511 353 40718 P276 S L G N L P V P P P P I H F D
Zebra Danio Brachydanio rerio NP_956499 303 34092 L226 G Q S F G E K L Q R V V S A A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VPT5 297 34525 I220 R K V G G T L I N P E A M P R
Honey Bee Apis mellifera XP_624974 285 32991 T208 W T Q E H Y S T N L L S L P I
Nematode Worm Caenorhab. elegans Q19189 359 41271 G280 L A K L T K T G L D G A I P S
Sea Urchin Strong. purpuratus XP_788130 354 40571 I276 L A A T S L P I P E P P K E R
Poplar Tree Populus trichocarpa XP_002325774 388 43941 P311 S A P T V Y P P P P P P P A P
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M841 393 44382 P316 S A P T V Y P P P P P P P A P
Baker's Yeast Sacchar. cerevisiae Q04370 399 45974 D311 R V N D L D E D I P R P P F S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 N.A. 92.1 N.A. 89.4 88.5 N.A. 46.7 76 64 51.5 N.A. 29.8 31.7 35.9 45.6
Protein Similarity: 100 99.7 N.A. 96 N.A. 93.3 92.7 N.A. 57.3 85.7 79.6 65.4 N.A. 47 49 56.2 68.5
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 0 100 20 0 N.A. 6.6 6.6 0 40
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 6.6 100 20 0 N.A. 26.6 26.6 13.3 53.3
Percent
Protein Identity: 31.9 N.A. N.A. 31.3 22.3 N.A.
Protein Similarity: 48.7 N.A. N.A. 48.3 40.3 N.A.
P-Site Identity: 40 N.A. N.A. 40 13.3 N.A.
P-Site Similarity: 46.6 N.A. N.A. 46.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 25 7 0 38 0 0 0 0 0 0 13 0 19 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 7 0 7 0 7 0 0 0 0 7 % D
% Glu: 0 0 0 13 0 7 7 0 0 7 7 0 0 7 0 % E
% Phe: 0 0 0 7 0 0 0 0 0 0 0 0 7 13 0 % F
% Gly: 7 7 13 7 13 0 0 7 0 0 7 0 0 0 0 % G
% His: 0 0 0 0 7 0 0 0 0 0 0 0 7 38 0 % H
% Ile: 0 0 0 0 0 0 0 13 7 0 0 7 7 0 7 % I
% Lys: 38 7 7 0 0 7 7 0 0 0 0 0 7 0 0 % K
% Leu: 13 7 38 7 13 44 7 7 7 7 13 0 7 7 38 % L
% Met: 0 0 0 0 0 7 0 0 0 0 0 0 7 0 0 % M
% Asn: 0 0 7 7 0 0 0 0 13 0 0 0 0 0 0 % N
% Pro: 0 0 13 0 0 7 57 19 63 69 63 63 19 19 19 % P
% Gln: 0 7 7 0 0 0 0 0 7 0 0 0 0 0 0 % Q
% Arg: 13 0 0 0 0 0 0 7 0 7 7 0 0 0 13 % R
% Ser: 19 38 7 0 7 0 13 0 0 0 0 7 7 0 13 % S
% Thr: 7 7 0 57 13 7 7 44 0 0 0 0 0 0 0 % T
% Val: 0 7 7 0 13 0 7 0 0 0 7 13 38 0 0 % V
% Trp: 7 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 19 0 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _