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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: E2F3 All Species: 2.42
Human Site: S71 Identified Species: 5.33
UniProt: O00716 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00716 NP_001940.1 465 49162 S71 N T S T T S C S S S L Q S G A
Chimpanzee Pan troglodytes XP_524538 437 47536 A56 Y P Q T A P P A A A P G T C L
Rhesus Macaque Macaca mulatta XP_001103396 425 46803 V45 S A P T S R P V A Q C P A C V
Dog Lupus familis XP_545361 509 56204 R72 S T P Y I L E R K A R Q G C C
Cat Felis silvestris
Mouse Mus musculus O35261 457 48739 C66 T N P S T T S C A T S L Q S G
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515449 468 50133 G64 P G P V G Q G G V G G V R A E
Chicken Gallus gallus Q90977 403 43534 I23 G A S P H L L I V S A S E E P
Frog Xenopus laevis NP_001090608 426 47125 G46 D V P A E A A G N P G L S E A
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q27368 805 87442 T118 H N T G A V A T A A A A A T A
Honey Bee Apis mellifera XP_396223 416 46049 S36 E E F L D E G S L D E V Q A Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001190160 404 44401 G24 A K I R T I L G V S P R G M L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 47.9 75.6 69.5 N.A. 94.1 N.A. N.A. 45 43.4 39.3 N.A. N.A. 20.5 30.7 N.A. 41
Protein Similarity: 100 60 79.5 73.8 N.A. 94.8 N.A. N.A. 55.5 56.9 55.9 N.A. N.A. 32.6 44.7 N.A. 54.6
P-Site Identity: 100 6.6 6.6 13.3 N.A. 6.6 N.A. N.A. 0 13.3 13.3 N.A. N.A. 6.6 6.6 N.A. 13.3
P-Site Similarity: 100 33.3 33.3 26.6 N.A. 33.3 N.A. N.A. 0 13.3 33.3 N.A. N.A. 46.6 6.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 19 0 10 19 10 19 10 37 28 19 10 19 19 28 % A
% Cys: 0 0 0 0 0 0 10 10 0 0 10 0 0 28 10 % C
% Asp: 10 0 0 0 10 0 0 0 0 10 0 0 0 0 0 % D
% Glu: 10 10 0 0 10 10 10 0 0 0 10 0 10 19 10 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 10 0 10 10 0 19 28 0 10 19 10 19 10 10 % G
% His: 10 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 10 10 0 10 0 0 0 0 0 0 0 % I
% Lys: 0 10 0 0 0 0 0 0 10 0 0 0 0 0 0 % K
% Leu: 0 0 0 10 0 19 19 0 10 0 10 19 0 0 19 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 10 19 0 0 0 0 0 0 10 0 0 0 0 0 0 % N
% Pro: 10 10 46 10 0 10 19 0 0 10 19 10 0 0 10 % P
% Gln: 0 0 10 0 0 10 0 0 0 10 0 19 19 0 10 % Q
% Arg: 0 0 0 10 0 10 0 10 0 0 10 10 10 0 0 % R
% Ser: 19 0 19 10 10 10 10 19 10 28 10 10 19 10 0 % S
% Thr: 10 19 10 28 28 10 0 10 0 10 0 0 10 10 0 % T
% Val: 0 10 0 10 0 10 0 10 28 0 0 19 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _