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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F3
All Species:
19.39
Human Site:
T222
Identified Species:
42.67
UniProt:
O00716
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00716
NP_001940.1
465
49162
T222
K
R
R
I
Y
D
I
T
N
V
L
E
G
I
H
Chimpanzee
Pan troglodytes
XP_524538
437
47536
M197
I
Q
W
V
G
R
G
M
F
E
D
P
T
R
P
Rhesus Macaque
Macaca mulatta
XP_001103396
425
46803
E186
Y
D
I
T
N
V
L
E
G
I
H
L
I
K
K
Dog
Lupus familis
XP_545361
509
56204
T266
K
R
R
I
Y
D
I
T
N
V
L
E
G
I
H
Cat
Felis silvestris
Mouse
Mus musculus
O35261
457
48739
T214
K
R
R
I
Y
D
I
T
N
V
L
E
G
I
H
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515449
468
50133
T223
K
R
R
I
Y
D
I
T
N
V
L
E
G
I
Q
Chicken
Gallus gallus
Q90977
403
43534
N164
I
T
K
K
S
K
N
N
I
Q
W
L
G
S
Q
Frog
Xenopus laevis
NP_001090608
426
47125
S187
I
Q
W
L
G
Y
T
S
S
V
E
F
S
S
R
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27368
805
87442
T298
K
R
R
I
Y
D
I
T
N
V
L
E
G
I
N
Honey Bee
Apis mellifera
XP_396223
416
46049
I177
Q
K
R
R
I
Y
D
I
T
N
V
L
E
G
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001190160
404
44401
E165
N
R
A
A
E
V
L
E
V
Q
K
R
R
I
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
75.6
69.5
N.A.
94.1
N.A.
N.A.
45
43.4
39.3
N.A.
N.A.
20.5
30.7
N.A.
41
Protein Similarity:
100
60
79.5
73.8
N.A.
94.8
N.A.
N.A.
55.5
56.9
55.9
N.A.
N.A.
32.6
44.7
N.A.
54.6
P-Site Identity:
100
0
0
100
N.A.
100
N.A.
N.A.
93.3
6.6
6.6
N.A.
N.A.
93.3
6.6
N.A.
13.3
P-Site Similarity:
100
13.3
13.3
100
N.A.
100
N.A.
N.A.
93.3
13.3
33.3
N.A.
N.A.
100
26.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
46
10
0
0
0
10
0
0
0
0
% D
% Glu:
0
0
0
0
10
0
0
19
0
10
10
46
10
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% F
% Gly:
0
0
0
0
19
0
10
0
10
0
0
0
55
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
28
% H
% Ile:
28
0
10
46
10
0
46
10
10
10
0
0
10
55
10
% I
% Lys:
46
10
10
10
0
10
0
0
0
0
10
0
0
10
10
% K
% Leu:
0
0
0
10
0
0
19
0
0
0
46
28
0
0
0
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
10
0
10
10
46
10
0
0
0
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% P
% Gln:
10
19
0
0
0
0
0
0
0
19
0
0
0
0
19
% Q
% Arg:
0
55
55
10
0
10
0
0
0
0
0
10
10
10
10
% R
% Ser:
0
0
0
0
10
0
0
10
10
0
0
0
10
19
0
% S
% Thr:
0
10
0
10
0
0
10
46
10
0
0
0
10
0
0
% T
% Val:
0
0
0
10
0
19
0
0
10
55
10
0
0
0
0
% V
% Trp:
0
0
19
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
10
0
0
0
46
19
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _