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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISLR
All Species:
20.91
Human Site:
Y389
Identified Species:
65.71
UniProt:
O14498
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14498
NP_005536.1
428
45997
Y389
E
D
N
V
V
I
I
Y
L
S
R
A
G
N
P
Chimpanzee
Pan troglodytes
XP_001164572
428
46049
Y389
E
D
N
V
V
I
I
Y
L
S
R
A
G
N
P
Rhesus Macaque
Macaca mulatta
XP_001097240
428
45833
Y389
E
D
N
V
V
I
I
Y
L
S
R
A
G
N
P
Dog
Lupus familis
XP_544768
428
45518
Y389
E
D
N
V
V
I
I
Y
L
S
R
A
G
A
P
Cat
Felis silvestris
Mouse
Mus musculus
Q6GU68
428
45596
Y389
E
D
N
V
V
I
I
Y
L
S
R
A
G
P
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508661
440
47314
Y386
E
D
N
I
V
I
I
Y
L
S
G
R
G
P
Q
Chicken
Gallus gallus
NP_001038132
699
77667
F593
E
K
H
M
A
A
D
F
D
P
R
A
S
Y
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781659
644
70684
P556
A
C
R
H
I
I
A
P
L
T
E
K
P
S
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
97.9
91.8
N.A.
86.6
N.A.
N.A.
57.9
29.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
21.7
Protein Similarity:
100
99.3
98.5
93.4
N.A.
90.4
N.A.
N.A.
69.5
42.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
36
P-Site Identity:
100
100
100
93.3
N.A.
93.3
N.A.
N.A.
66.6
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
N.A.
N.A.
73.3
40
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
0
0
13
13
13
0
0
0
0
75
0
13
0
% A
% Cys:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
75
0
0
0
0
13
0
13
0
0
0
0
0
0
% D
% Glu:
88
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
13
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
13
0
75
0
0
% G
% His:
0
0
13
13
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
13
13
88
75
0
0
0
0
0
0
0
13
% I
% Lys:
0
13
0
0
0
0
0
0
0
0
0
13
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
88
0
0
0
0
0
13
% L
% Met:
0
0
0
13
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
75
0
0
0
0
0
0
0
0
0
0
38
0
% N
% Pro:
0
0
0
0
0
0
0
13
0
13
0
0
13
25
63
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% Q
% Arg:
0
0
13
0
0
0
0
0
0
0
75
13
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
75
0
0
13
13
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
13
0
0
0
0
0
% T
% Val:
0
0
0
63
75
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
75
0
0
0
0
0
13
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _