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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NRG2
All Species:
19.7
Human Site:
S526
Identified Species:
48.15
UniProt:
O14511
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14511
NP_004874.1
850
91679
S526
H
T
W
S
L
E
R
S
E
S
L
T
S
D
S
Chimpanzee
Pan troglodytes
XP_001168800
640
70369
S339
F
S
T
S
H
Y
T
S
T
A
H
H
S
T
T
Rhesus Macaque
Macaca mulatta
XP_001086071
640
70368
S339
F
S
T
S
H
Y
T
S
T
A
H
H
S
T
T
Dog
Lupus familis
XP_856268
868
92802
S535
H
T
W
S
L
E
R
S
E
S
L
T
S
D
S
Cat
Felis silvestris
Mouse
Mus musculus
P56974
756
82195
S455
M
L
S
S
V
G
T
S
K
C
N
S
P
A
C
Rat
Rattus norvegicus
O35569
868
93758
S550
H
T
W
S
L
E
R
S
E
S
L
T
S
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508509
829
89843
T524
E
T
E
T
S
F
S
T
S
H
Y
T
S
T
T
Chicken
Gallus gallus
Q05199
602
67435
Y301
T
S
F
S
T
S
H
Y
T
S
T
T
H
H
S
Frog
Xenopus laevis
O93383
677
75776
W376
T
Q
T
P
S
H
S
W
S
N
G
L
S
E
S
Zebra Danio
Brachydanio rerio
XP_687232
717
79706
S416
S
S
R
S
H
H
T
S
T
A
S
H
T
S
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.4
31.8
92.7
N.A.
83.5
93.7
N.A.
32
28.2
28.8
46.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
44.7
45.1
93.4
N.A.
85.2
94.6
N.A.
45.1
42
43.8
59.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
20
20
100
N.A.
13.3
100
N.A.
20
26.6
13.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
40
40
100
N.A.
33.3
100
N.A.
40
40
26.6
40
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
30
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
10
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
30
0
% D
% Glu:
10
0
10
0
0
30
0
0
30
0
0
0
0
10
0
% E
% Phe:
20
0
10
0
0
10
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
0
0
0
0
10
0
0
0
0
% G
% His:
30
0
0
0
30
20
10
0
0
10
20
30
10
10
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% K
% Leu:
0
10
0
0
30
0
0
0
0
0
30
10
0
0
0
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
10
0
0
0
10
% N
% Pro:
0
0
0
10
0
0
0
0
0
0
0
0
10
0
0
% P
% Gln:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
10
0
0
0
30
0
0
0
0
0
0
0
0
% R
% Ser:
10
40
10
80
20
10
20
70
20
40
10
10
70
10
50
% S
% Thr:
20
40
30
10
10
0
40
10
40
0
10
50
10
30
30
% T
% Val:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
30
0
0
0
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
20
0
10
0
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _