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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NRG2
All Species:
4.55
Human Site:
Y677
Identified Species:
11.11
UniProt:
O14511
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14511
NP_004874.1
850
91679
Y677
M
Q
R
S
Y
D
S
Y
Y
Y
P
A
A
G
P
Chimpanzee
Pan troglodytes
XP_001168800
640
70369
F471
P
S
M
V
V
S
P
F
V
E
E
E
R
P
L
Rhesus Macaque
Macaca mulatta
XP_001086071
640
70368
F471
P
S
M
A
V
S
P
F
V
E
E
E
R
P
L
Dog
Lupus familis
XP_856268
868
92802
G694
P
G
P
G
P
G
P
G
P
G
P
G
P
G
P
Cat
Felis silvestris
Mouse
Mus musculus
P56974
756
82195
A587
Y
D
S
Y
Y
Y
P
A
A
G
P
G
P
R
R
Rat
Rattus norvegicus
O35569
868
93758
Y695
M
Q
R
S
Y
D
S
Y
Y
Y
P
A
A
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508509
829
89843
P660
V
P
S
V
A
V
S
P
F
I
E
E
E
R
P
Chicken
Gallus gallus
Q05199
602
67435
P433
I
P
S
V
A
V
S
P
F
M
D
E
E
R
P
Frog
Xenopus laevis
O93383
677
75776
E508
V
S
P
P
R
L
R
E
K
R
Y
D
R
K
T
Zebra Danio
Brachydanio rerio
XP_687232
717
79706
P548
A
S
H
A
L
S
L
P
P
A
A
S
A
I
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.4
31.8
92.7
N.A.
83.5
93.7
N.A.
32
28.2
28.8
46.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
44.7
45.1
93.4
N.A.
85.2
94.6
N.A.
45.1
42
43.8
59.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
0
20
N.A.
13.3
100
N.A.
13.3
13.3
0
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
6.6
13.3
20
N.A.
13.3
100
N.A.
26.6
26.6
6.6
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
20
20
0
0
10
10
10
10
20
30
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
20
0
0
0
0
10
10
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
10
0
20
30
40
20
0
0
% E
% Phe:
0
0
0
0
0
0
0
20
20
0
0
0
0
0
0
% F
% Gly:
0
10
0
10
0
10
0
10
0
20
0
20
0
30
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
0
10
0
0
0
10
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
0
0
0
10
0
% K
% Leu:
0
0
0
0
10
10
10
0
0
0
0
0
0
0
20
% L
% Met:
20
0
20
0
0
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
30
20
20
10
10
0
40
30
20
0
40
0
20
20
50
% P
% Gln:
0
20
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
20
0
10
0
10
0
0
10
0
0
30
30
10
% R
% Ser:
0
40
30
20
0
30
40
0
0
0
0
10
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% T
% Val:
20
0
0
30
20
20
0
0
20
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
10
30
10
0
20
20
20
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _