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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SOCS3 All Species: 20.91
Human Site: S106 Identified Species: 41.82
UniProt: O14543 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14543 NP_003946.3 225 24770 S106 G G S F S L Q S D P R S T Q P
Chimpanzee Pan troglodytes XP_509267 198 22155 L81 D S S H S D Y L L T I S V K T
Rhesus Macaque Macaca mulatta XP_001106015 576 62574 S457 G G S F S L Q S D P R S T Q P
Dog Lupus familis XP_848851 225 24779 S106 G G S F S L Q S D P R S T Q P
Cat Felis silvestris
Mouse Mus musculus O35718 225 24758 S106 G G S F S L Q S D P R S T Q P
Rat Rattus norvegicus O88583 225 24790 S106 G G S F S L Q S D P R S T Q P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516256 214 23730 C97 T K N L R I Q C E G G C F S L
Chicken Gallus gallus Q90X67 209 23158 N92 K T E S G T K N L R I Q C E G
Frog Xenopus laevis P13116 532 59718 G209 K I R K L D S G G F Y I T S R
Zebra Danio Brachydanio rerio NP_998469 210 23421 T93 T L S V K T A T G T K N L R I
Tiger Blowfish Takifugu rubipres NP_001072096 201 22742 F84 S S D N R H L F A L S I K T A
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_799032 227 25956 Y106 T T S V R I E Y E D G L F M L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 28 38.5 97.7 N.A. 96.8 95.5 N.A. 79.5 84 20.1 61.3 57.3 N.A. N.A. N.A. 35.2
Protein Similarity: 100 45.3 38.8 99.1 N.A. 97.3 96.4 N.A. 86.2 88.4 28.2 74.6 70.6 N.A. N.A. N.A. 52.4
P-Site Identity: 100 20 100 100 N.A. 100 100 N.A. 6.6 0 6.6 6.6 0 N.A. N.A. N.A. 6.6
P-Site Similarity: 100 26.6 100 100 N.A. 100 100 N.A. 26.6 20 6.6 33.3 0 N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 9 0 9 0 0 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 9 9 0 0 % C
% Asp: 9 0 9 0 0 17 0 0 42 9 0 0 0 0 0 % D
% Glu: 0 0 9 0 0 0 9 0 17 0 0 0 0 9 0 % E
% Phe: 0 0 0 42 0 0 0 9 0 9 0 0 17 0 0 % F
% Gly: 42 42 0 0 9 0 0 9 17 9 17 0 0 0 9 % G
% His: 0 0 0 9 0 9 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 9 0 0 0 17 0 0 0 0 17 17 0 0 9 % I
% Lys: 17 9 0 9 9 0 9 0 0 0 9 0 9 9 0 % K
% Leu: 0 9 0 9 9 42 9 9 17 9 0 9 9 0 17 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % M
% Asn: 0 0 9 9 0 0 0 9 0 0 0 9 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 42 0 0 0 0 42 % P
% Gln: 0 0 0 0 0 0 50 0 0 0 0 9 0 42 0 % Q
% Arg: 0 0 9 0 25 0 0 0 0 9 42 0 0 9 9 % R
% Ser: 9 17 67 9 50 0 9 42 0 0 9 50 0 17 0 % S
% Thr: 25 17 0 0 0 17 0 9 0 17 0 0 50 9 9 % T
% Val: 0 0 0 17 0 0 0 0 0 0 0 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 9 9 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _