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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SOCS3 All Species: 17.58
Human Site: T141 Identified Species: 35.15
UniProt: O14543 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14543 NP_003946.3 225 24770 T141 P S F P S P P T E P S S E V P
Chimpanzee Pan troglodytes XP_509267 198 22155 K115 S I I C V K S K L K Q F D S V
Rhesus Macaque Macaca mulatta XP_001106015 576 62574 T492 P S F P S P P T E P S S E V P
Dog Lupus familis XP_848851 225 24779 T141 P S F P A P P T E P S S E V S
Cat Felis silvestris
Mouse Mus musculus O35718 225 24758 T141 P S F S L P P T E P S S E V P
Rat Rattus norvegicus O88583 225 24790 T141 P S F S L P P T E P S F E V Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516256 214 23730 S131 V H H Y M P P S S C S S S T S
Chicken Gallus gallus Q90X67 209 23158 H126 C V L K L V H H Y M P P T P C
Frog Xenopus laevis P13116 532 59718 E414 A R L I E D N E Y T A R Q G A
Zebra Danio Brachydanio rerio NP_998469 210 23421 K127 P R F D C V L K L I H H Y M P
Tiger Blowfish Takifugu rubipres NP_001072096 201 22742 V118 D P K N I Q T V P H F D C V L
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_799032 227 25956 E142 Y Y M R M S R E K N F V D A N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 28 38.5 97.7 N.A. 96.8 95.5 N.A. 79.5 84 20.1 61.3 57.3 N.A. N.A. N.A. 35.2
Protein Similarity: 100 45.3 38.8 99.1 N.A. 97.3 96.4 N.A. 86.2 88.4 28.2 74.6 70.6 N.A. N.A. N.A. 52.4
P-Site Identity: 100 0 100 86.6 N.A. 86.6 73.3 N.A. 26.6 0 0 20 6.6 N.A. N.A. N.A. 0
P-Site Similarity: 100 6.6 100 93.3 N.A. 86.6 73.3 N.A. 33.3 0 13.3 26.6 6.6 N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 0 9 0 0 0 0 0 9 0 0 9 9 % A
% Cys: 9 0 0 9 9 0 0 0 0 9 0 0 9 0 9 % C
% Asp: 9 0 0 9 0 9 0 0 0 0 0 9 17 0 0 % D
% Glu: 0 0 0 0 9 0 0 17 42 0 0 0 42 0 0 % E
% Phe: 0 0 50 0 0 0 0 0 0 0 17 17 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % G
% His: 0 9 9 0 0 0 9 9 0 9 9 9 0 0 0 % H
% Ile: 0 9 9 9 9 0 0 0 0 9 0 0 0 0 0 % I
% Lys: 0 0 9 9 0 9 0 17 9 9 0 0 0 0 0 % K
% Leu: 0 0 17 0 25 0 9 0 17 0 0 0 0 0 9 % L
% Met: 0 0 9 0 17 0 0 0 0 9 0 0 0 9 0 % M
% Asn: 0 0 0 9 0 0 9 0 0 9 0 0 0 0 9 % N
% Pro: 50 9 0 25 0 50 50 0 9 42 9 9 0 9 34 % P
% Gln: 0 0 0 0 0 9 0 0 0 0 9 0 9 0 9 % Q
% Arg: 0 17 0 9 0 0 9 0 0 0 0 9 0 0 0 % R
% Ser: 9 42 0 17 17 9 9 9 9 0 50 42 9 9 17 % S
% Thr: 0 0 0 0 0 0 9 42 0 9 0 0 9 9 0 % T
% Val: 9 9 0 0 9 17 0 9 0 0 0 9 0 50 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 9 0 9 0 0 0 0 17 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _