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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOCS6
All Species:
22.73
Human Site:
S244
Identified Species:
41.67
UniProt:
O14544
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14544
NP_004223.2
535
59528
S244
S
R
S
Y
C
L
D
S
S
S
P
M
E
V
S
Chimpanzee
Pan troglodytes
XP_512211
535
59559
S244
S
R
S
Y
C
L
D
S
S
S
P
M
E
V
S
Rhesus Macaque
Macaca mulatta
XP_001095656
535
59456
S244
S
R
S
Y
C
L
D
S
S
S
P
M
E
V
S
Dog
Lupus familis
XP_533377
535
59510
G244
P
R
S
Y
C
L
D
G
S
S
P
M
E
V
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9JLY0
533
58875
T242
P
R
S
C
C
L
D
T
S
S
P
M
E
V
S
Rat
Rattus norvegicus
XP_001063512
547
60813
T256
P
R
S
C
C
L
D
T
S
S
P
M
E
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506079
518
56852
P234
P
L
E
E
G
M
Y
P
L
E
G
S
R
S
C
Chicken
Gallus gallus
NP_001120784
534
59819
S243
S
R
S
Y
C
L
D
S
S
S
P
M
E
V
S
Frog
Xenopus laevis
NP_001086732
533
60367
R243
S
R
A
F
C
L
D
R
S
S
P
M
E
I
S
Zebra Danio
Brachydanio rerio
XP_687041
519
57925
G235
A
Q
S
F
C
L
D
G
P
S
P
M
E
V
G
Tiger Blowfish
Takifugu rubipres
NP_001116334
531
59124
S243
H
S
F
C
L
D
S
S
S
P
M
E
V
V
T
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624532
358
41531
Q74
N
Y
D
P
S
A
V
Q
N
N
K
S
T
I
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780887
391
44540
A107
R
C
D
V
N
D
N
A
E
I
F
E
E
R
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.5
94.5
N.A.
84.3
82.4
N.A.
77.5
90.2
81.6
70.4
72.7
N.A.
30
N.A.
30
Protein Similarity:
100
99.6
98.8
96.4
N.A.
88.7
87.1
N.A.
83.3
95.5
91.4
81.6
83.5
N.A.
46.1
N.A.
45.7
P-Site Identity:
100
100
100
86.6
N.A.
80
80
N.A.
0
100
73.3
60
20
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
6.6
100
93.3
80
26.6
N.A.
33.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
8
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
8
0
24
70
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
16
0
0
16
70
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
8
8
0
0
0
0
8
8
0
16
77
0
0
% E
% Phe:
0
0
8
16
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
16
0
0
8
0
0
0
8
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
0
0
16
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% K
% Leu:
0
8
0
0
8
70
0
0
8
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
8
0
0
0
0
8
70
0
0
0
% M
% Asn:
8
0
0
0
8
0
8
0
8
8
0
0
0
0
0
% N
% Pro:
31
0
0
8
0
0
0
8
8
8
70
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% Q
% Arg:
8
62
0
0
0
0
0
8
0
0
0
0
8
8
0
% R
% Ser:
39
8
62
0
8
0
8
39
70
70
0
16
0
8
70
% S
% Thr:
0
0
0
0
0
0
0
16
0
0
0
0
8
0
8
% T
% Val:
0
0
0
8
0
0
8
0
0
0
0
0
8
70
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
39
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _