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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOCS6
All Species:
24.85
Human Site:
S299
Identified Species:
45.56
UniProt:
O14544
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14544
NP_004223.2
535
59528
S299
T
T
G
V
M
L
Q
S
P
R
A
G
H
D
D
Chimpanzee
Pan troglodytes
XP_512211
535
59559
S299
T
T
G
V
M
L
Q
S
P
R
A
G
H
D
D
Rhesus Macaque
Macaca mulatta
XP_001095656
535
59456
S299
T
T
G
V
M
L
Q
S
P
R
A
G
H
D
D
Dog
Lupus familis
XP_533377
535
59510
S299
T
T
G
V
M
L
Q
S
P
R
A
S
H
D
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9JLY0
533
58875
S297
T
T
G
V
M
L
Q
S
P
R
G
G
H
D
D
Rat
Rattus norvegicus
XP_001063512
547
60813
S311
T
T
G
V
M
L
Q
S
P
R
G
G
H
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506079
518
56852
P286
P
I
S
L
C
S
S
P
S
P
F
P
P
P
L
Chicken
Gallus gallus
NP_001120784
534
59819
N298
T
T
G
V
V
L
Q
N
P
R
V
N
H
S
D
Frog
Xenopus laevis
NP_001086732
533
60367
N297
T
N
G
V
L
F
Q
N
S
R
V
N
H
N
D
Zebra Danio
Brachydanio rerio
XP_687041
519
57925
S287
P
A
M
V
L
S
N
S
R
A
D
T
P
L
F
Tiger Blowfish
Takifugu rubipres
NP_001116334
531
59124
S296
S
A
G
V
M
L
Q
S
C
T
V
D
V
P
P
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624532
358
41531
L126
Y
R
D
I
E
E
K
L
E
D
I
N
K
Q
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780887
391
44540
D159
Q
W
Q
L
Q
G
A
D
S
V
R
S
K
N
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.5
94.5
N.A.
84.3
82.4
N.A.
77.5
90.2
81.6
70.4
72.7
N.A.
30
N.A.
30
Protein Similarity:
100
99.6
98.8
96.4
N.A.
88.7
87.1
N.A.
83.3
95.5
91.4
81.6
83.5
N.A.
46.1
N.A.
45.7
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
0
66.6
46.6
13.3
40
N.A.
0
N.A.
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
6.6
80
66.6
20
46.6
N.A.
13.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
0
8
0
0
8
31
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
8
0
8
8
8
0
47
62
% D
% Glu:
0
0
0
0
8
8
0
0
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
8
% F
% Gly:
0
0
70
0
0
8
0
0
0
0
16
39
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
62
0
0
% H
% Ile:
0
8
0
8
0
0
0
0
0
0
8
0
0
0
8
% I
% Lys:
0
0
0
0
0
0
8
0
0
0
0
0
16
0
0
% K
% Leu:
0
0
0
16
16
62
0
8
0
0
0
0
0
8
8
% L
% Met:
0
0
8
0
54
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
8
0
0
0
0
8
16
0
0
0
24
0
16
0
% N
% Pro:
16
0
0
0
0
0
0
8
54
8
0
8
16
16
8
% P
% Gln:
8
0
8
0
8
0
70
0
0
0
0
0
0
8
0
% Q
% Arg:
0
8
0
0
0
0
0
0
8
62
8
0
0
0
0
% R
% Ser:
8
0
8
0
0
16
8
62
24
0
0
16
0
8
0
% S
% Thr:
62
54
0
0
0
0
0
0
0
8
0
8
0
0
0
% T
% Val:
0
0
0
77
8
0
0
0
0
8
24
0
8
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _