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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOCS6
All Species:
35.45
Human Site:
Y220
Identified Species:
65
UniProt:
O14544
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14544
NP_004223.2
535
59528
Y220
I
G
L
M
P
Q
D
Y
I
Q
Y
T
V
P
L
Chimpanzee
Pan troglodytes
XP_512211
535
59559
Y220
I
G
L
M
P
Q
D
Y
I
Q
Y
T
V
P
L
Rhesus Macaque
Macaca mulatta
XP_001095656
535
59456
Y220
I
G
L
M
P
Q
D
Y
I
Q
Y
T
V
P
L
Dog
Lupus familis
XP_533377
535
59510
Y220
I
G
L
M
P
Q
D
Y
I
Q
Y
T
V
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9JLY0
533
58875
Y218
I
G
L
M
S
Q
D
Y
L
Q
Y
T
V
P
L
Rat
Rattus norvegicus
XP_001063512
547
60813
Y232
I
G
L
M
S
Q
D
Y
L
Q
Y
T
V
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506079
518
56852
V210
R
L
H
I
D
D
H
V
P
V
V
I
G
L
V
Chicken
Gallus gallus
NP_001120784
534
59819
Y219
I
G
L
M
P
Q
D
Y
I
Q
Y
T
V
P
L
Frog
Xenopus laevis
NP_001086732
533
60367
Y219
L
G
L
M
P
Q
D
Y
I
Q
Y
T
V
P
L
Zebra Danio
Brachydanio rerio
XP_687041
519
57925
D211
P
I
G
L
T
P
Q
D
Y
I
Q
Y
T
M
P
Tiger Blowfish
Takifugu rubipres
NP_001116334
531
59124
Y219
L
G
L
T
P
Q
D
Y
I
Q
Y
T
M
P
L
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624532
358
41531
D50
E
N
Q
K
K
K
E
D
L
I
E
T
K
E
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780887
391
44540
V83
R
Y
N
F
P
L
P
V
P
S
E
K
H
C
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.5
94.5
N.A.
84.3
82.4
N.A.
77.5
90.2
81.6
70.4
72.7
N.A.
30
N.A.
30
Protein Similarity:
100
99.6
98.8
96.4
N.A.
88.7
87.1
N.A.
83.3
95.5
91.4
81.6
83.5
N.A.
46.1
N.A.
45.7
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
0
100
93.3
0
80
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
13.3
100
100
6.6
93.3
N.A.
33.3
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
8
8
70
16
0
0
0
0
0
0
8
% D
% Glu:
8
0
0
0
0
0
8
0
0
0
16
0
0
8
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
70
8
0
0
0
0
0
0
0
0
0
8
0
0
% G
% His:
0
0
8
0
0
0
8
0
0
0
0
0
8
0
0
% H
% Ile:
54
8
0
8
0
0
0
0
54
16
0
8
0
0
0
% I
% Lys:
0
0
0
8
8
8
0
0
0
0
0
8
8
0
0
% K
% Leu:
16
8
70
8
0
8
0
0
24
0
0
0
0
8
70
% L
% Met:
0
0
0
62
0
0
0
0
0
0
0
0
8
8
0
% M
% Asn:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
62
8
8
0
16
0
0
0
0
70
8
% P
% Gln:
0
0
8
0
0
70
8
0
0
70
8
0
0
0
0
% Q
% Arg:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
16
0
0
0
0
8
0
0
0
0
0
% S
% Thr:
0
0
0
8
8
0
0
0
0
0
0
77
8
0
0
% T
% Val:
0
0
0
0
0
0
0
16
0
8
8
0
62
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
70
8
0
70
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _