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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
COPE
All Species:
9.09
Human Site:
Y249
Identified Species:
15.38
UniProt:
O14579
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14579
NP_009194.2
308
34482
Y249
A
L
D
K
D
S
G
Y
P
E
T
L
V
N
L
Chimpanzee
Pan troglodytes
XP_001137184
331
36905
Y272
A
L
D
K
D
S
G
Y
P
E
T
L
V
N
L
Rhesus Macaque
Macaca mulatta
XP_001114807
308
34452
Y249
A
L
D
K
D
S
G
Y
P
E
T
L
V
N
L
Dog
Lupus familis
XP_852205
308
34510
H249
A
L
D
K
D
S
G
H
P
E
T
L
I
N
L
Cat
Felis silvestris
Mouse
Mus musculus
O89079
308
34549
H249
A
L
D
K
D
S
G
H
P
E
T
L
I
N
L
Rat
Rattus norvegicus
NP_001099546
166
18646
M108
V
L
E
L
D
R
E
M
S
R
S
V
D
V
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515042
306
34392
H247
A
L
D
K
D
S
S
H
A
E
T
L
I
N
L
Chicken
Gallus gallus
Q5ZIK9
308
34350
H249
A
L
D
K
D
S
G
H
P
E
T
L
I
N
F
Frog
Xenopus laevis
NP_001085327
299
33968
H240
A
L
D
K
D
S
S
H
P
E
T
L
I
N
F
Zebra Danio
Brachydanio rerio
NP_001007365
300
34014
H241
A
L
D
K
D
S
G
H
P
E
T
L
I
N
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393328
300
34733
N241
S
L
D
K
D
S
N
N
P
D
T
L
I
N
M
Nematode Worm
Caenorhab. elegans
O62246
292
32785
R231
L
L
E
S
A
L
E
R
D
N
K
D
A
D
V
Sea Urchin
Strong. purpuratus
XP_787154
291
33045
C233
N
L
A
V
D
S
N
C
P
E
T
L
I
N
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O64748
293
32640
D224
C
M
Q
M
G
N
F
D
E
A
E
T
L
L
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.7
99
94.1
N.A.
90.5
49.6
N.A.
82.4
78.9
77.2
76.6
N.A.
N.A.
62.3
36
49
Protein Similarity:
100
92.7
99.6
97.4
N.A.
95.4
51.2
N.A.
91.5
91.8
90.2
89.6
N.A.
N.A.
77.9
59.4
66.2
P-Site Identity:
100
100
100
86.6
N.A.
86.6
13.3
N.A.
73.3
80
73.3
86.6
N.A.
N.A.
60
6.6
53.3
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
86.6
93.3
86.6
100
N.A.
N.A.
86.6
26.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
63.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
65
0
8
0
8
0
0
0
8
8
0
0
8
0
0
% A
% Cys:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
72
0
86
0
0
8
8
8
0
8
8
8
0
% D
% Glu:
0
0
15
0
0
0
15
0
8
72
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
15
% F
% Gly:
0
0
0
0
8
0
50
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
43
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
58
0
0
% I
% Lys:
0
0
0
72
0
0
0
0
0
0
8
0
0
0
0
% K
% Leu:
8
93
0
8
0
8
0
0
0
0
0
79
8
8
58
% L
% Met:
0
8
0
8
0
0
0
8
0
0
0
0
0
0
15
% M
% Asn:
8
0
0
0
0
8
15
8
0
8
0
0
0
79
0
% N
% Pro:
0
0
0
0
0
0
0
0
72
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
8
0
8
0
8
0
0
0
0
0
% R
% Ser:
8
0
0
8
0
79
15
0
8
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
79
8
0
0
8
% T
% Val:
8
0
0
8
0
0
0
0
0
0
0
8
22
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
22
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _