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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC42EP2
All Species:
9.09
Human Site:
S158
Identified Species:
22.22
UniProt:
O14613
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14613
NP_006770.1
210
22484
S158
W
R
I
P
E
T
G
S
P
N
S
G
L
T
P
Chimpanzee
Pan troglodytes
XP_001169517
210
22488
S158
W
R
I
P
E
T
G
S
P
H
S
G
L
T
P
Rhesus Macaque
Macaca mulatta
XP_001113902
210
22479
S158
W
R
I
P
E
T
G
S
P
H
S
G
L
T
P
Dog
Lupus familis
XP_540865
214
22914
P158
S
V
D
I
W
R
I
P
E
A
G
S
V
H
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZX9
214
22979
P158
N
V
D
V
W
R
I
P
E
A
G
S
P
H
N
Rat
Rattus norvegicus
Q5PQP4
214
23030
P158
N
V
D
I
W
R
V
P
E
A
G
L
P
H
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510360
257
27876
R159
E
K
L
Q
E
K
S
R
P
G
E
D
A
T
P
Chicken
Gallus gallus
XP_426134
253
27922
Q159
K
L
Q
E
K
S
K
Q
T
E
N
G
E
T
Y
Frog
Xenopus laevis
NP_001085535
234
25896
Q159
F
A
S
I
P
L
D
Q
E
S
S
N
L
V
P
Zebra Danio
Brachydanio rerio
NP_001013549
247
26564
R158
L
E
E
R
S
I
T
R
H
A
S
L
P
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.5
90.6
N.A.
87.3
86.4
N.A.
38.9
39.5
28.2
49.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
100
93.9
N.A.
92.5
91.1
N.A.
51.7
49.7
43.1
57.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
93.3
0
N.A.
0
0
N.A.
26.6
13.3
20
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
6.6
N.A.
0
0
N.A.
40
33.3
33.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
0
40
0
0
10
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
30
0
0
0
10
0
0
0
0
10
0
0
0
% D
% Glu:
10
10
10
10
40
0
0
0
40
10
10
0
10
0
0
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
30
0
0
10
30
40
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
10
20
0
0
0
30
0
% H
% Ile:
0
0
30
30
0
10
20
0
0
0
0
0
0
0
0
% I
% Lys:
10
10
0
0
10
10
10
0
0
0
0
0
0
0
0
% K
% Leu:
10
10
10
0
0
10
0
0
0
0
0
20
40
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
20
0
0
0
0
0
0
0
0
10
10
10
0
0
30
% N
% Pro:
0
0
0
30
10
0
0
30
40
0
0
0
30
0
50
% P
% Gln:
0
0
10
10
0
0
0
20
0
0
0
0
0
0
0
% Q
% Arg:
0
30
0
10
0
30
0
20
0
0
0
0
0
0
0
% R
% Ser:
10
0
10
0
10
10
10
30
0
10
50
20
0
0
10
% S
% Thr:
0
0
0
0
0
30
10
0
10
0
0
0
0
50
0
% T
% Val:
0
30
0
10
0
0
10
0
0
0
0
0
10
10
0
% V
% Trp:
30
0
0
0
30
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _