KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DVL2
All Species:
14.85
Human Site:
S614
Identified Species:
36.3
UniProt:
O14641
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14641
NP_004413.1
736
78948
S614
P
E
E
R
A
P
E
S
K
S
G
S
G
S
E
Chimpanzee
Pan troglodytes
Q5IS48
670
72833
E566
R
A
P
G
R
E
K
E
R
R
A
A
G
A
G
Rhesus Macaque
Macaca mulatta
XP_001106375
736
78825
S614
P
E
E
R
A
P
E
S
K
S
G
S
G
S
E
Dog
Lupus familis
XP_546582
736
78909
S614
P
E
E
R
A
P
E
S
K
S
G
S
G
S
E
Cat
Felis silvestris
Mouse
Mus musculus
Q60838
736
78784
S614
P
E
E
R
A
P
E
S
K
S
G
S
G
S
E
Rat
Rattus norvegicus
Q9WVB9
695
75429
E590
H
R
T
P
G
R
E
E
R
R
A
T
G
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422756
833
90624
S725
S
G
G
S
G
S
E
S
D
H
T
T
R
S
S
Frog
Xenopus laevis
P51142
736
79769
G609
D
D
R
S
G
V
A
G
V
G
G
G
D
S
K
Zebra Danio
Brachydanio rerio
NP_997813
747
81808
G598
V
S
E
S
T
V
G
G
S
V
R
D
D
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P51140
623
68898
L519
I
T
S
D
I
G
P
L
P
N
P
P
I
Y
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59.3
98.9
97.2
N.A.
96.4
61
N.A.
N.A.
57
75.6
72
N.A.
40.3
N.A.
N.A.
N.A.
Protein Similarity:
100
70.7
99.1
98
N.A.
97
72.6
N.A.
N.A.
66.9
82.6
82.1
N.A.
54.3
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
100
100
N.A.
100
13.3
N.A.
N.A.
20
13.3
6.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
33.3
100
100
N.A.
100
33.3
N.A.
N.A.
26.6
26.6
6.6
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
40
0
10
0
0
0
20
10
0
20
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
10
0
0
0
0
10
0
0
10
20
0
0
% D
% Glu:
0
40
50
0
0
10
60
20
0
0
0
0
0
0
40
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
10
10
30
10
10
20
0
10
50
10
60
0
20
% G
% His:
10
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
10
0
0
0
10
0
0
0
0
0
0
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
10
0
40
0
0
0
0
10
10
% K
% Leu:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% N
% Pro:
40
0
10
10
0
40
10
0
10
0
10
10
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
10
10
40
10
10
0
0
20
20
10
0
10
0
0
% R
% Ser:
10
10
10
30
0
10
0
50
10
40
0
40
0
60
20
% S
% Thr:
0
10
10
0
10
0
0
0
0
0
10
20
0
0
0
% T
% Val:
10
0
0
0
0
20
0
0
10
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _