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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRS4
All Species:
4.55
Human Site:
T620
Identified Species:
14.29
UniProt:
O14654
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14654
NP_003595.1
1257
133768
T620
R
S
Y
F
G
K
L
T
Q
S
K
Q
Q
Q
M
Chimpanzee
Pan troglodytes
XP_001134895
1241
131474
D602
R
G
G
H
H
R
P
D
S
S
T
L
H
T
D
Rhesus Macaque
Macaca mulatta
XP_001092171
1113
119935
F548
G
P
H
R
A
R
A
F
D
E
D
E
D
D
P
Dog
Lupus familis
XP_549179
1343
142162
T624
R
S
Y
F
G
K
L
T
Q
S
K
Q
Q
Q
M
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0Y7
1216
130128
G614
P
P
P
P
P
A
A
G
A
T
G
G
K
G
K
Rat
Rattus norvegicus
P35570
1235
131160
P597
R
R
G
G
H
H
R
P
D
S
S
N
L
H
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026741
1240
131795
L590
E
G
L
E
M
H
P
L
E
R
R
A
G
R
T
Frog
Xenopus laevis
Q9DF49
1074
117892
R508
T
H
S
Q
P
D
S
R
D
D
Y
M
E
A
D
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
25.1
83.9
78.2
N.A.
76.2
25.2
N.A.
N.A.
21.5
29.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
39.1
85.1
82.4
N.A.
81.6
39.8
N.A.
N.A.
36.2
42.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
13.3
0
100
N.A.
0
13.3
N.A.
N.A.
0
0
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
20
100
N.A.
13.3
13.3
N.A.
N.A.
20
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
13
13
25
0
13
0
0
13
0
13
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
13
0
13
38
13
13
0
13
13
25
% D
% Glu:
13
0
0
13
0
0
0
0
13
13
0
13
13
0
0
% E
% Phe:
0
0
0
25
0
0
0
13
0
0
0
0
0
0
0
% F
% Gly:
13
25
25
13
25
0
0
13
0
0
13
13
13
13
0
% G
% His:
0
13
13
13
25
25
0
0
0
0
0
0
13
13
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
25
0
0
0
0
25
0
13
0
13
% K
% Leu:
0
0
13
0
0
0
25
13
0
0
0
13
13
0
0
% L
% Met:
0
0
0
0
13
0
0
0
0
0
0
13
0
0
25
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% N
% Pro:
13
25
13
13
25
0
25
13
0
0
0
0
0
0
13
% P
% Gln:
0
0
0
13
0
0
0
0
25
0
0
25
25
25
0
% Q
% Arg:
50
13
0
13
0
25
13
13
0
13
13
0
0
13
0
% R
% Ser:
0
25
13
0
0
0
13
0
13
50
13
0
0
0
0
% S
% Thr:
13
0
0
0
0
0
0
25
0
13
13
0
0
13
25
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
25
0
0
0
0
0
0
0
13
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _