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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM10
All Species:
39.09
Human Site:
S706
Identified Species:
71.67
UniProt:
O14672
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14672
NP_001101.1
748
84142
S706
C
S
V
H
T
P
S
S
N
P
K
L
P
P
P
Chimpanzee
Pan troglodytes
XP_001172381
674
75447
S632
C
S
V
H
T
P
S
S
N
P
K
L
P
P
P
Rhesus Macaque
Macaca mulatta
XP_001097016
748
84119
S706
C
S
V
H
T
P
S
S
N
P
K
L
P
P
P
Dog
Lupus familis
XP_535496
747
84085
S705
C
S
V
H
T
P
S
S
N
P
K
L
P
P
P
Cat
Felis silvestris
Mouse
Mus musculus
O35598
749
83949
S707
C
S
V
H
T
P
S
S
N
P
K
L
P
P
P
Rat
Rattus norvegicus
Q10743
544
60426
P508
S
S
N
P
K
L
P
P
P
K
P
L
P
G
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506337
735
82442
A698
I
A
L
I
M
L
M
A
G
F
I
K
I
C
S
Chicken
Gallus gallus
NP_989592
749
84579
S707
C
S
V
H
T
P
S
S
N
P
K
L
P
P
H
Frog
Xenopus laevis
Q8JIY1
749
84049
S707
C
S
V
H
T
P
S
S
N
P
K
L
P
P
P
Zebra Danio
Brachydanio rerio
NP_956714
780
87221
S711
C
S
V
H
T
P
S
S
N
P
K
L
P
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VAC5
732
83062
L696
K
L
R
H
E
M
K
L
I
E
W
S
Q
K
L
Honey Bee
Apis mellifera
XP_393114
899
99822
S780
C
A
V
H
T
P
S
S
N
P
K
K
P
P
A
Nematode Worm
Caenorhab. elegans
NP_492377
922
101555
T774
C
A
V
H
T
P
S
T
N
P
N
K
P
P
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.1
99.4
96.7
N.A.
95.8
70.9
N.A.
88
89.5
80.5
74.3
N.A.
27.9
43.2
33.9
N.A.
Protein Similarity:
100
90.1
99.4
98.9
N.A.
97.8
72
N.A.
91.3
94.6
88.9
84.6
N.A.
45.5
56
48.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
20
N.A.
0
93.3
100
100
N.A.
6.6
80
66.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
20
93.3
100
100
N.A.
6.6
86.6
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
0
0
0
0
0
8
0
0
0
0
0
0
16
% A
% Cys:
77
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% G
% His:
0
0
0
85
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
8
0
0
8
0
0
0
0
8
0
8
0
8
0
0
% I
% Lys:
8
0
0
0
8
0
8
0
0
8
70
24
0
8
0
% K
% Leu:
0
8
8
0
0
16
0
8
0
0
0
70
0
0
8
% L
% Met:
0
0
0
0
8
8
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
77
0
8
0
0
0
0
% N
% Pro:
0
0
0
8
0
77
8
8
8
77
8
0
85
77
54
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
70
0
0
0
0
77
70
0
0
0
8
0
0
8
% S
% Thr:
0
0
0
0
77
0
0
8
0
0
0
0
0
0
8
% T
% Val:
0
0
77
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _