Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADAM10 All Species: 26.97
Human Site: S740 Identified Species: 49.44
UniProt: O14672 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14672 NP_001101.1 748 84142 S740 Q R Q R P R E S Y Q M G H M R
Chimpanzee Pan troglodytes XP_001172381 674 75447 S666 Q R Q R P R E S Y Q M G H M R
Rhesus Macaque Macaca mulatta XP_001097016 748 84119 S740 Q R Q R P R E S Y Q M G H M R
Dog Lupus familis XP_535496 747 84085 S739 Q R Q R P R E S Y Q M G H M R
Cat Felis silvestris
Mouse Mus musculus O35598 749 83949 S741 P R Q R P R E S Y Q M G H M R
Rat Rattus norvegicus Q10743 544 60426 S536 Q R Q R P R E S Y Q M G H M R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506337 735 82442 R727 P L P G K R K R K R E G K T A
Chicken Gallus gallus NP_989592 749 84579 S741 Q R Q R P R E S Y Q M G H M R
Frog Xenopus laevis Q8JIY1 749 84049 N741 S R Q R P R E N Y Q M G H M R
Zebra Danio Brachydanio rerio NP_956714 780 87221 N772 H H R S A R E N Y Q M G Q M R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VAC5 732 83062 K724 H I R V P R Q K I S V A R A C
Honey Bee Apis mellifera XP_393114 899 99822 A890 G G G G R A S A Y E M R H H N
Nematode Worm Caenorhab. elegans NP_492377 922 101555 N901 P R R G H R K N K R Q T S S D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.1 99.4 96.7 N.A. 95.8 70.9 N.A. 88 89.5 80.5 74.3 N.A. 27.9 43.2 33.9 N.A.
Protein Similarity: 100 90.1 99.4 98.9 N.A. 97.8 72 N.A. 91.3 94.6 88.9 84.6 N.A. 45.5 56 48.7 N.A.
P-Site Identity: 100 100 100 100 N.A. 93.3 100 N.A. 13.3 100 86.6 53.3 N.A. 13.3 20 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 93.3 100 N.A. 26.6 100 93.3 66.6 N.A. 33.3 33.3 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 8 0 8 0 0 0 8 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % D
% Glu: 0 0 0 0 0 0 70 0 0 8 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 8 8 24 0 0 0 0 0 0 0 77 0 0 0 % G
% His: 16 8 0 0 8 0 0 0 0 0 0 0 70 8 0 % H
% Ile: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 8 0 16 8 16 0 0 0 8 0 0 % K
% Leu: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 77 0 0 70 0 % M
% Asn: 0 0 0 0 0 0 0 24 0 0 0 0 0 0 8 % N
% Pro: 24 0 8 0 70 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 47 0 62 0 0 0 8 0 0 70 8 0 8 0 0 % Q
% Arg: 0 70 24 62 8 93 0 8 0 16 0 8 8 0 70 % R
% Ser: 8 0 0 8 0 0 8 54 0 8 0 0 8 8 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 8 0 8 0 % T
% Val: 0 0 0 8 0 0 0 0 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 77 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _