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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APAF1
All Species:
22.42
Human Site:
S211
Identified Species:
49.33
UniProt:
O14727
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14727
NP_001151.1
1248
141840
S211
T
R
L
D
Q
D
E
S
F
S
Q
R
L
P
L
Chimpanzee
Pan troglodytes
XP_509290
1248
141889
S211
T
R
L
D
Q
D
E
S
F
S
Q
R
L
P
L
Rhesus Macaque
Macaca mulatta
XP_001087067
1248
142132
S211
T
R
L
D
Q
D
E
S
F
S
Q
R
L
P
L
Dog
Lupus familis
XP_539737
1250
142155
N212
T
R
L
D
Q
D
E
N
F
S
Q
R
P
P
L
Cat
Felis silvestris
Mouse
Mus musculus
O88879
1249
140870
S211
M
R
L
D
Q
D
E
S
F
S
Q
R
L
P
L
Rat
Rattus norvegicus
Q9EPV5
1249
141134
S211
T
R
L
G
Q
E
E
S
F
S
Q
R
L
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505891
1250
142195
N211
M
R
F
D
Q
G
S
N
F
S
Q
R
P
P
L
Chicken
Gallus gallus
XP_416167
1243
141542
T205
S
R
L
E
H
D
S
T
L
P
Q
R
P
P
L
Frog
Xenopus laevis
NP_001085834
1248
141557
K211
T
R
L
D
Q
E
A
K
Y
S
Q
R
P
P
L
Zebra Danio
Brachydanio rerio
Q9I9H8
1261
142916
S211
F
R
L
E
Q
C
Q
S
S
D
T
S
Q
R
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001199578
1250
139666
D221
A
R
L
D
E
D
V
D
R
S
P
P
H
N
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.2
90.8
N.A.
87.5
87.3
N.A.
81.1
69.7
60.7
54.8
N.A.
N.A.
N.A.
N.A.
34.4
Protein Similarity:
100
99.8
98.4
94.9
N.A.
93.8
93.9
N.A.
89.6
82.3
76.8
74
N.A.
N.A.
N.A.
N.A.
54.8
P-Site Identity:
100
100
100
86.6
N.A.
93.3
86.6
N.A.
60
46.6
66.6
26.6
N.A.
N.A.
N.A.
N.A.
40
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
66.6
66.6
80
40
N.A.
N.A.
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
73
0
64
0
10
0
10
0
0
0
0
0
% D
% Glu:
0
0
0
19
10
19
55
0
0
0
0
0
0
0
0
% E
% Phe:
10
0
10
0
0
0
0
0
64
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% K
% Leu:
0
0
91
0
0
0
0
0
10
0
0
0
46
0
91
% L
% Met:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
19
0
0
0
0
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
10
10
10
37
82
10
% P
% Gln:
0
0
0
0
82
0
10
0
0
0
82
0
10
0
0
% Q
% Arg:
0
100
0
0
0
0
0
0
10
0
0
82
0
10
0
% R
% Ser:
10
0
0
0
0
0
19
55
10
82
0
10
0
0
0
% S
% Thr:
55
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% T
% Val:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _