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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APAF1 All Species: 27.27
Human Site: T472 Identified Species: 60
UniProt: O14727 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14727 NP_001151.1 1248 141840 T472 Q R Y H Q P H T L S P D Q E D
Chimpanzee Pan troglodytes XP_509290 1248 141889 T472 Q R Y H Q P H T L S P D Q E D
Rhesus Macaque Macaca mulatta XP_001087067 1248 142132 T472 Q R Y H Q P H T L S P D Q E D
Dog Lupus familis XP_539737 1250 142155 T473 Q K H Y Q P H T L S P D Q E D
Cat Felis silvestris
Mouse Mus musculus O88879 1249 140870 T472 Q R Y Y Q P H T L S P D Q E D
Rat Rattus norvegicus Q9EPV5 1249 141134 T472 Q R Y H Q P H T L S P G Q E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505891 1250 142195 T472 Q K Y Y Q L R T L S P D Q D D
Chicken Gallus gallus XP_416167 1243 141542 V466 K R Y Y K L H V P V L S Q E D
Frog Xenopus laevis NP_001085834 1248 141557 L472 K K H Y S S K L P T V E Q E D
Zebra Danio Brachydanio rerio Q9I9H8 1261 142916 P474 Q R F Y S K R P P D S A D K D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001199578 1250 139666 S480 S F H S H C K S E Y H T L P D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 97.2 90.8 N.A. 87.5 87.3 N.A. 81.1 69.7 60.7 54.8 N.A. N.A. N.A. N.A. 34.4
Protein Similarity: 100 99.8 98.4 94.9 N.A. 93.8 93.9 N.A. 89.6 82.3 76.8 74 N.A. N.A. N.A. N.A. 54.8
P-Site Identity: 100 100 100 80 N.A. 93.3 93.3 N.A. 66.6 40 20 20 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 93.3 N.A. 86.6 60 60 40 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % A
% Cys: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 10 0 55 10 10 100 % D
% Glu: 0 0 0 0 0 0 0 0 10 0 0 10 0 73 0 % E
% Phe: 0 10 10 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % G
% His: 0 0 28 37 10 0 64 0 0 0 10 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 19 28 0 0 10 10 19 0 0 0 0 0 0 10 0 % K
% Leu: 0 0 0 0 0 19 0 10 64 0 10 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 55 0 10 28 0 64 0 0 10 0 % P
% Gln: 73 0 0 0 64 0 0 0 0 0 0 0 82 0 0 % Q
% Arg: 0 64 0 0 0 0 19 0 0 0 0 0 0 0 0 % R
% Ser: 10 0 0 10 19 10 0 10 0 64 10 10 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 64 0 10 0 10 0 0 0 % T
% Val: 0 0 0 0 0 0 0 10 0 10 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 64 55 0 0 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _