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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APAF1
All Species:
41.82
Human Site:
Y341
Identified Species:
92
UniProt:
O14727
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14727
NP_001151.1
1248
141840
Y341
F
P
N
R
W
E
Y
Y
L
K
Q
L
Q
N
K
Chimpanzee
Pan troglodytes
XP_509290
1248
141889
Y341
F
P
N
R
W
E
Y
Y
L
K
Q
L
Q
N
K
Rhesus Macaque
Macaca mulatta
XP_001087067
1248
142132
Y341
F
P
N
R
W
E
Y
Y
L
K
Q
L
Q
N
K
Dog
Lupus familis
XP_539737
1250
142155
Y342
F
P
N
R
W
D
Y
Y
L
R
Q
L
Q
N
K
Cat
Felis silvestris
Mouse
Mus musculus
O88879
1249
140870
Y341
F
P
N
R
W
A
Y
Y
L
R
Q
L
Q
N
K
Rat
Rattus norvegicus
Q9EPV5
1249
141134
Y341
F
P
N
R
W
A
Y
Y
L
R
Q
L
Q
N
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505891
1250
142195
Y341
F
P
N
R
W
E
Y
Y
L
R
Q
L
Q
N
K
Chicken
Gallus gallus
XP_416167
1243
141542
Y335
F
P
S
R
W
E
Y
Y
L
K
Q
L
Q
N
K
Frog
Xenopus laevis
NP_001085834
1248
141557
Y341
F
P
T
R
W
D
F
Y
L
T
Q
L
K
R
K
Zebra Danio
Brachydanio rerio
Q9I9H8
1261
142916
Y343
F
P
D
R
W
S
Y
Y
L
R
Q
L
Q
Q
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001199578
1250
139666
Y349
H
P
T
R
W
K
Y
Y
L
D
K
L
T
R
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.2
90.8
N.A.
87.5
87.3
N.A.
81.1
69.7
60.7
54.8
N.A.
N.A.
N.A.
N.A.
34.4
Protein Similarity:
100
99.8
98.4
94.9
N.A.
93.8
93.9
N.A.
89.6
82.3
76.8
74
N.A.
N.A.
N.A.
N.A.
54.8
P-Site Identity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
93.3
93.3
60
73.3
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
100
80
86.6
N.A.
N.A.
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
19
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
19
0
0
0
10
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
46
0
0
0
0
0
0
0
0
0
% E
% Phe:
91
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
10
0
0
0
37
10
0
10
0
100
% K
% Leu:
0
0
0
0
0
0
0
0
100
0
0
100
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
64
0
0
0
0
0
0
0
0
0
0
73
0
% N
% Pro:
0
100
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
91
0
82
10
0
% Q
% Arg:
0
0
0
100
0
0
0
0
0
46
0
0
0
19
0
% R
% Ser:
0
0
10
0
0
10
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
19
0
0
0
0
0
0
10
0
0
10
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
100
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
91
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _