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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K7
All Species:
34.55
Human Site:
S247
Identified Species:
58.46
UniProt:
O14733
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14733
NP_660186.1
419
47485
S247
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
Chimpanzee
Pan troglodytes
XP_001146898
522
57631
S343
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
Rhesus Macaque
Macaca mulatta
XP_001098659
367
41194
E201
P
S
N
I
L
L
D
E
R
G
Q
I
K
L
C
Dog
Lupus familis
XP_868281
419
47531
S247
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CE90
535
59294
S263
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
Rat
Rattus norvegicus
Q4KSH7
419
47517
S247
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q07192
446
50082
S280
I
H
R
D
I
K
P
S
N
I
L
L
D
T
N
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
H195
S
I
V
K
A
L
E
H
L
H
S
N
L
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q23977
1178
125089
S324
I
H
R
D
V
K
P
S
N
I
L
I
D
E
R
Honey Bee
Apis mellifera
XP_396834
762
86143
S227
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
P197
I
I
H
R
D
V
K
P
S
N
I
L
V
D
G
Sea Urchin
Strong. purpuratus
XP_795810
281
31449
K115
S
G
N
K
E
E
N
K
R
I
L
M
D
L
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A06
354
39192
H188
H
H
E
R
R
I
I
H
R
D
L
K
P
S
N
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
T489
I
H
R
D
V
K
P
T
N
I
L
C
S
A
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
77
83.5
99
N.A.
77.1
99
N.A.
N.A.
N.A.
40.3
39.3
N.A.
22.4
35.2
34.8
43.6
Protein Similarity:
100
78.1
83.7
99.5
N.A.
77.5
99.5
N.A.
N.A.
N.A.
54.4
56.7
N.A.
27.5
43.3
52
54.4
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
N.A.
N.A.
80
0
N.A.
93.3
100
13.3
20
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
N.A.
N.A.
86.6
0
N.A.
100
100
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.5
25.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.2
39.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
66.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% C
% Asp:
0
0
0
65
8
0
8
0
0
8
0
0
65
8
8
% D
% Glu:
0
0
8
0
8
8
8
8
0
0
0
0
0
50
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
8
% G
% His:
8
72
8
0
0
0
0
15
0
8
0
0
0
0
0
% H
% Ile:
72
15
0
8
8
8
8
0
0
72
8
15
0
0
0
% I
% Lys:
0
0
0
15
0
65
8
8
0
0
0
8
8
0
0
% K
% Leu:
0
0
0
0
8
15
0
0
8
0
79
58
8
15
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
15
0
0
0
8
0
65
8
0
8
0
0
22
% N
% Pro:
8
0
0
0
0
0
65
8
0
0
0
0
8
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
65
15
8
0
0
0
22
0
0
0
0
0
50
% R
% Ser:
15
8
0
0
0
0
0
58
8
0
8
0
8
15
0
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% T
% Val:
0
0
8
0
58
8
0
0
0
0
0
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _