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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP2K7 All Species: 32.12
Human Site: Y299 Identified Species: 54.36
UniProt: O14733 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14733 NP_660186.1 419 47485 Y299 P D P T K P D Y D I R A D V W
Chimpanzee Pan troglodytes XP_001146898 522 57631 Y395 P D P T K P D Y D I R A D V W
Rhesus Macaque Macaca mulatta XP_001098659 367 41194 R250 T K P D Y D I R A D V W S L G
Dog Lupus familis XP_868281 419 47531 Y299 P D P T K P D Y D I R A D V W
Cat Felis silvestris
Mouse Mus musculus Q8CE90 535 59294 Y315 P D P T K P D Y D I R A D V W
Rat Rattus norvegicus Q4KSH7 419 47517 Y299 P D P T K P D Y D I R A D V W
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q07192 446 50082 Q329 I D P S A S R Q G Y D V R S D
Zebra Danio Brachydanio rerio Q9DGE0 361 40575 K244 K T M D A G C K P Y M A P E R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q23977 1178 125089 Y373 I D P K K P K Y D I R A D V W
Honey Bee Apis mellifera XP_396834 762 86143 Y279 P D P T K P D Y D I R A D V W
Nematode Worm Caenorhab. elegans Q20347 363 41178 Y246 R I T S S D K Y D V R S D V W
Sea Urchin Strong. purpuratus XP_795810 281 31449 L164 L D K L I K K L R E P V P E Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94A06 354 39192 I237 P Y M S P E R I S G S L Y S N
Baker's Yeast Sacchar. cerevisiae P08018 668 72701 Y541 L N P D R A T Y T V Q S D I W
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 77 83.5 99 N.A. 77.1 99 N.A. N.A. N.A. 40.3 39.3 N.A. 22.4 35.2 34.8 43.6
Protein Similarity: 100 78.1 83.7 99.5 N.A. 77.5 99.5 N.A. N.A. N.A. 54.4 56.7 N.A. 27.5 43.3 52 54.4
P-Site Identity: 100 100 6.6 100 N.A. 100 100 N.A. N.A. N.A. 13.3 6.6 N.A. 80 100 40 6.6
P-Site Similarity: 100 100 13.3 100 N.A. 100 100 N.A. N.A. N.A. 20 6.6 N.A. 80 100 60 6.6
Percent
Protein Identity: N.A. N.A. N.A. 29.5 25.6 N.A.
Protein Similarity: N.A. N.A. N.A. 48.2 39.6 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 15 8 0 0 8 0 0 58 0 0 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 0 65 0 22 0 15 43 0 58 8 8 0 65 0 8 % D
% Glu: 0 0 0 0 0 8 0 0 0 8 0 0 0 15 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 0 0 8 8 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 15 8 0 0 8 0 8 8 0 50 0 0 0 8 0 % I
% Lys: 8 8 8 8 50 8 22 8 0 0 0 0 0 0 0 % K
% Leu: 15 0 0 8 0 0 0 8 0 0 0 8 0 8 0 % L
% Met: 0 0 15 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 50 0 72 0 8 50 0 0 8 0 8 0 15 0 0 % P
% Gln: 0 0 0 0 0 0 0 8 0 0 8 0 0 0 8 % Q
% Arg: 8 0 0 0 8 0 15 8 8 0 58 0 8 0 8 % R
% Ser: 0 0 0 22 8 8 0 0 8 0 8 15 8 15 0 % S
% Thr: 8 8 8 43 0 0 8 0 8 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 15 8 15 0 58 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 65 % W
% Tyr: 0 8 0 0 8 0 0 65 0 15 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _