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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRMT5
All Species:
30.3
Human Site:
S15
Identified Species:
47.62
UniProt:
O14744
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14744
NP_001034708.1
637
72684
S15
G
A
G
G
S
R
V
S
S
G
R
D
L
N
C
Chimpanzee
Pan troglodytes
XP_509844
617
70208
S15
G
A
G
G
S
R
V
S
S
G
R
D
L
N
C
Rhesus Macaque
Macaca mulatta
XP_001103964
644
73482
S22
G
A
G
G
S
R
V
S
S
G
R
D
L
N
C
Dog
Lupus familis
XP_537366
637
72639
S15
G
A
G
G
S
R
V
S
S
G
R
D
L
N
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIG8
637
72661
S15
G
A
G
G
S
R
V
S
S
G
R
D
L
N
C
Rat
Rattus norvegicus
NP_001102337
637
72676
S15
G
A
G
G
S
R
V
S
S
G
R
D
L
N
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084480
633
72267
N30
D
T
L
G
A
M
A
N
Q
G
F
D
F
L
C
Zebra Danio
Brachydanio rerio
NP_001007184
631
71873
S11
G
S
A
G
S
R
V
S
C
G
R
D
L
S
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9U6Y9
610
69722
I19
V
N
S
I
P
K
L
I
E
K
A
F
A
N
N
Honey Bee
Apis mellifera
XP_394141
622
71088
C14
V
S
C
G
L
D
F
C
A
A
P
D
L
S
N
Nematode Worm
Caenorhab. elegans
P46580
734
83274
S27
E
E
Q
M
S
S
G
S
S
P
K
S
N
S
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002324705
645
72400
S12
E
K
A
G
F
E
K
S
Q
S
R
Y
C
G
V
Maize
Zea mays
NP_001141438
651
72748
D12
Q
R
S
G
D
K
S
D
S
R
Y
C
G
V
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GWT4
642
71852
T12
E
R
G
G
W
E
R
T
E
S
R
Y
C
G
V
Baker's Yeast
Sacchar. cerevisiae
P38274
827
95135
F13
F
V
G
V
K
P
G
F
N
H
K
Q
H
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.4
98.9
99.3
N.A.
97.8
97.8
N.A.
N.A.
N.A.
83.6
78.6
N.A.
39.2
52.7
32.8
N.A.
Protein Similarity:
100
94.1
98.9
99.8
N.A.
99
99
N.A.
N.A.
N.A.
93
87.5
N.A.
56.6
69.2
49.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
26.6
73.3
N.A.
6.6
20
20
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
40
86.6
N.A.
20
40
33.3
N.A.
Percent
Protein Identity:
46.3
47.7
N.A.
46.8
22.8
N.A.
Protein Similarity:
63.8
63.2
N.A.
64.9
40.6
N.A.
P-Site Identity:
20
13.3
N.A.
20
6.6
N.A.
P-Site Similarity:
20
20
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
40
14
0
7
0
7
0
7
7
7
0
7
0
0
% A
% Cys:
0
0
7
0
0
0
0
7
7
0
0
7
14
0
54
% C
% Asp:
7
0
0
0
7
7
0
7
0
0
0
60
0
0
0
% D
% Glu:
20
7
0
0
0
14
0
0
14
0
0
0
0
0
7
% E
% Phe:
7
0
0
0
7
0
7
7
0
0
7
7
7
0
0
% F
% Gly:
47
0
54
80
0
0
14
0
0
54
0
0
7
14
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% H
% Ile:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% I
% Lys:
0
7
0
0
7
14
7
0
0
7
14
0
0
0
7
% K
% Leu:
0
0
7
0
7
0
7
0
0
0
0
0
54
7
0
% L
% Met:
0
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
0
0
7
7
0
0
0
7
47
14
% N
% Pro:
0
0
0
0
7
7
0
0
0
7
7
0
0
0
7
% P
% Gln:
7
0
7
0
0
0
0
0
14
0
0
7
0
0
0
% Q
% Arg:
0
14
0
0
0
47
7
0
0
7
60
0
0
0
0
% R
% Ser:
0
14
14
0
54
7
7
60
54
14
0
7
0
27
0
% S
% Thr:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% T
% Val:
14
7
0
7
0
0
47
0
0
0
0
0
0
7
14
% V
% Trp:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
14
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _