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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRMT5
All Species:
28.48
Human Site:
S279
Identified Species:
44.76
UniProt:
O14744
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14744
NP_001034708.1
637
72684
S279
H
S
E
K
E
F
C
S
Y
L
Q
Y
L
E
Y
Chimpanzee
Pan troglodytes
XP_509844
617
70208
H271
F
I
I
T
G
T
N
H
H
S
E
K
E
F
C
Rhesus Macaque
Macaca mulatta
XP_001103964
644
73482
S286
H
S
E
K
E
F
C
S
Y
L
Q
Y
L
E
Y
Dog
Lupus familis
XP_537366
637
72639
S279
H
S
E
K
E
F
C
S
Y
L
Q
Y
L
E
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIG8
637
72661
S279
H
S
E
K
E
F
C
S
Y
L
Q
Y
L
E
Y
Rat
Rattus norvegicus
NP_001102337
637
72676
S279
H
S
E
K
E
F
C
S
Y
L
Q
Y
L
E
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084480
633
72267
S275
H
S
E
K
D
L
C
S
Y
L
Q
Y
L
E
Y
Zebra Danio
Brachydanio rerio
NP_001007184
631
71873
S275
H
S
E
K
D
L
R
S
Y
L
Q
Y
L
E
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9U6Y9
610
69722
K255
I
S
T
N
P
N
D
K
A
L
C
Q
Y
A
D
Honey Bee
Apis mellifera
XP_394141
622
71088
Y264
N
R
Y
Q
S
I
T
Y
Y
H
N
Y
L
E
Y
Nematode Worm
Caenorhab. elegans
P46580
734
83274
N331
A
L
R
H
A
V
R
N
V
N
Y
R
S
R
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002324705
645
72400
P289
P
Q
R
H
S
L
R
P
Y
L
D
Y
V
G
F
Maize
Zea mays
NP_001141438
651
72748
P294
Y
V
R
H
A
L
A
P
Y
L
E
Y
I
A
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GWT4
642
71852
I285
T
E
K
N
P
L
R
I
Y
L
D
Y
V
A
Y
Baker's Yeast
Sacchar. cerevisiae
P38274
827
95135
E300
G
G
E
S
A
Y
L
E
Y
I
N
Y
L
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.4
98.9
99.3
N.A.
97.8
97.8
N.A.
N.A.
N.A.
83.6
78.6
N.A.
39.2
52.7
32.8
N.A.
Protein Similarity:
100
94.1
98.9
99.8
N.A.
99
99
N.A.
N.A.
N.A.
93
87.5
N.A.
56.6
69.2
49.7
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
N.A.
N.A.
86.6
80
N.A.
13.3
33.3
0
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
86.6
N.A.
13.3
46.6
6.6
N.A.
Percent
Protein Identity:
46.3
47.7
N.A.
46.8
22.8
N.A.
Protein Similarity:
63.8
63.2
N.A.
64.9
40.6
N.A.
P-Site Identity:
20
26.6
N.A.
26.6
26.6
N.A.
P-Site Similarity:
33.3
46.6
N.A.
40
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
20
0
7
0
7
0
0
0
0
20
0
% A
% Cys:
0
0
0
0
0
0
40
0
0
0
7
0
0
0
7
% C
% Asp:
0
0
0
0
14
0
7
0
0
0
14
0
0
0
7
% D
% Glu:
0
7
54
0
34
0
0
7
0
0
14
0
7
54
0
% E
% Phe:
7
0
0
0
0
34
0
0
0
0
0
0
0
7
7
% F
% Gly:
7
7
0
0
7
0
0
0
0
0
0
0
0
7
0
% G
% His:
47
0
0
20
0
0
0
7
7
7
0
0
0
0
0
% H
% Ile:
7
7
7
0
0
7
0
7
0
7
0
0
7
0
0
% I
% Lys:
0
0
7
47
0
0
0
7
0
0
0
7
0
0
7
% K
% Leu:
0
7
0
0
0
34
7
0
0
74
0
0
60
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
14
0
7
7
7
0
7
14
0
0
0
0
% N
% Pro:
7
0
0
0
14
0
0
14
0
0
0
0
0
0
7
% P
% Gln:
0
7
0
7
0
0
0
0
0
0
47
7
0
0
0
% Q
% Arg:
0
7
20
0
0
0
27
0
0
0
0
7
0
7
0
% R
% Ser:
0
54
0
7
14
0
0
47
0
7
0
0
7
0
0
% S
% Thr:
7
0
7
7
0
7
7
0
0
0
0
0
0
0
0
% T
% Val:
0
7
0
0
0
7
0
0
7
0
0
0
14
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
7
0
0
7
0
7
80
0
7
80
7
0
67
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _