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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRMT5
All Species:
44.24
Human Site:
S463
Identified Species:
69.52
UniProt:
O14744
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14744
NP_001034708.1
637
72684
S463
F
L
K
D
D
G
V
S
I
P
G
E
Y
T
S
Chimpanzee
Pan troglodytes
XP_509844
617
70208
L450
N
E
L
S
P
E
C
L
D
G
A
Q
H
F
L
Rhesus Macaque
Macaca mulatta
XP_001103964
644
73482
S470
F
L
K
D
D
G
V
S
I
P
G
E
Y
T
S
Dog
Lupus familis
XP_537366
637
72639
S463
F
L
K
D
D
G
V
S
I
P
G
E
Y
T
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIG8
637
72661
S463
F
L
K
D
D
G
V
S
I
P
G
E
Y
T
S
Rat
Rattus norvegicus
NP_001102337
637
72676
S463
F
L
K
D
D
G
V
S
I
P
G
E
Y
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084480
633
72267
S459
F
L
K
D
D
G
V
S
I
P
G
E
Y
T
S
Zebra Danio
Brachydanio rerio
NP_001007184
631
71873
S459
F
L
K
D
D
G
V
S
I
P
C
S
Y
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9U6Y9
610
69722
S440
L
L
K
P
D
G
I
S
I
P
Y
K
S
T
S
Honey Bee
Apis mellifera
XP_394141
622
71088
C448
F
L
K
V
D
G
I
C
I
P
T
S
Y
T
S
Nematode Worm
Caenorhab. elegans
P46580
734
83274
S527
F
L
K
P
T
T
I
S
I
P
Q
K
Y
T
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002324705
645
72400
S473
F
L
K
Q
D
G
I
S
I
P
S
S
Y
T
S
Maize
Zea mays
NP_001141438
651
72748
S479
F
L
K
P
D
G
I
S
I
P
S
S
Y
T
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GWT4
642
71852
S470
F
L
K
P
D
G
I
S
I
P
S
S
Y
T
S
Baker's Yeast
Sacchar. cerevisiae
P38274
827
95135
F492
H
S
H
N
D
T
I
F
I
P
R
S
Y
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.4
98.9
99.3
N.A.
97.8
97.8
N.A.
N.A.
N.A.
83.6
78.6
N.A.
39.2
52.7
32.8
N.A.
Protein Similarity:
100
94.1
98.9
99.8
N.A.
99
99
N.A.
N.A.
N.A.
93
87.5
N.A.
56.6
69.2
49.7
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
86.6
N.A.
60
66.6
60
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
86.6
N.A.
73.3
73.3
73.3
N.A.
Percent
Protein Identity:
46.3
47.7
N.A.
46.8
22.8
N.A.
Protein Similarity:
63.8
63.2
N.A.
64.9
40.6
N.A.
P-Site Identity:
73.3
73.3
N.A.
73.3
33.3
N.A.
P-Site Similarity:
80
80
N.A.
80
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
7
7
0
0
7
0
0
0
0
% C
% Asp:
0
0
0
47
87
0
0
0
7
0
0
0
0
0
0
% D
% Glu:
0
7
0
0
0
7
0
0
0
0
0
40
0
0
0
% E
% Phe:
80
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% F
% Gly:
0
0
0
0
0
80
0
0
0
7
40
0
0
0
0
% G
% His:
7
0
7
0
0
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
0
0
0
0
0
0
47
0
94
0
0
0
0
0
0
% I
% Lys:
0
0
87
0
0
0
0
0
0
0
0
14
0
0
0
% K
% Leu:
7
87
7
0
0
0
0
7
0
0
0
0
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
27
7
0
0
0
0
94
0
0
0
0
0
% P
% Gln:
0
0
0
7
0
0
0
0
0
0
7
7
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% R
% Ser:
0
7
0
7
0
0
0
80
0
0
20
40
7
7
94
% S
% Thr:
0
0
0
0
7
14
0
0
0
0
7
0
0
87
0
% T
% Val:
0
0
0
7
0
0
47
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
0
87
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _