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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRMT5
All Species:
50.3
Human Site:
S573
Identified Species:
79.05
UniProt:
O14744
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14744
NP_001034708.1
637
72684
S573
S
I
R
P
E
T
H
S
P
G
M
F
S
W
F
Chimpanzee
Pan troglodytes
XP_509844
617
70208
Y554
V
L
H
G
F
A
G
Y
F
E
T
V
L
Y
Q
Rhesus Macaque
Macaca mulatta
XP_001103964
644
73482
S580
S
I
R
P
E
T
H
S
P
G
M
F
S
W
F
Dog
Lupus familis
XP_537366
637
72639
S573
S
I
R
P
E
T
H
S
P
G
M
F
S
W
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIG8
637
72661
S573
S
I
R
P
E
T
H
S
P
G
M
F
S
W
F
Rat
Rattus norvegicus
NP_001102337
637
72676
S573
S
I
R
P
E
T
H
S
P
G
M
F
S
W
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084480
633
72267
S569
S
I
C
P
E
S
H
S
P
G
M
F
S
W
F
Zebra Danio
Brachydanio rerio
NP_001007184
631
71873
S567
S
I
K
P
E
T
H
S
P
G
M
F
S
W
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9U6Y9
610
69722
T546
S
I
N
P
L
T
H
T
P
G
M
F
S
W
F
Honey Bee
Apis mellifera
XP_394141
622
71088
S558
S
I
E
P
S
T
H
S
P
G
M
F
S
W
F
Nematode Worm
Caenorhab. elegans
P46580
734
83274
T664
S
I
E
P
S
T
H
T
P
G
M
V
S
W
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002324705
645
72400
T581
G
I
E
P
S
M
A
T
P
N
M
F
S
W
F
Maize
Zea mays
NP_001141438
651
72748
T587
G
I
E
P
N
T
A
T
P
N
M
F
S
W
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GWT4
642
71852
T578
G
I
E
P
T
T
A
T
P
N
M
F
S
W
F
Baker's Yeast
Sacchar. cerevisiae
P38274
827
95135
T631
L
I
K
K
C
D
H
T
P
N
M
T
S
W
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.4
98.9
99.3
N.A.
97.8
97.8
N.A.
N.A.
N.A.
83.6
78.6
N.A.
39.2
52.7
32.8
N.A.
Protein Similarity:
100
94.1
98.9
99.8
N.A.
99
99
N.A.
N.A.
N.A.
93
87.5
N.A.
56.6
69.2
49.7
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
N.A.
N.A.
86.6
93.3
N.A.
80
86.6
73.3
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
100
N.A.
86.6
86.6
80
N.A.
Percent
Protein Identity:
46.3
47.7
N.A.
46.8
22.8
N.A.
Protein Similarity:
63.8
63.2
N.A.
64.9
40.6
N.A.
P-Site Identity:
53.3
60
N.A.
60
40
N.A.
P-Site Similarity:
60
66.6
N.A.
66.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
20
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
34
0
47
0
0
0
0
7
0
0
0
0
0
% E
% Phe:
0
0
0
0
7
0
0
0
7
0
0
80
0
0
87
% F
% Gly:
20
0
0
7
0
0
7
0
0
67
0
0
0
0
0
% G
% His:
0
0
7
0
0
0
74
0
0
0
0
0
0
0
0
% H
% Ile:
0
94
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
14
7
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
7
7
0
0
7
0
0
0
0
0
0
0
7
0
0
% L
% Met:
0
0
0
0
0
7
0
0
0
0
94
0
0
0
0
% M
% Asn:
0
0
7
0
7
0
0
0
0
27
0
0
0
0
0
% N
% Pro:
0
0
0
87
0
0
0
0
94
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
34
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
67
0
0
0
20
7
0
54
0
0
0
0
94
0
7
% S
% Thr:
0
0
0
0
7
74
0
40
0
0
7
7
0
0
0
% T
% Val:
7
0
0
0
0
0
0
0
0
0
0
14
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
94
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _