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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRMT5
All Species:
22.12
Human Site:
T176
Identified Species:
34.76
UniProt:
O14744
Number Species:
14
Phosphosite Substitution
Charge Score:
0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14744
NP_001034708.1
637
72684
T176
E
N
A
P
T
T
H
T
E
E
Y
S
G
E
E
Chimpanzee
Pan troglodytes
XP_509844
617
70208
T176
E
N
A
P
T
T
H
T
E
E
Y
S
G
E
E
Rhesus Macaque
Macaca mulatta
XP_001103964
644
73482
T183
E
N
A
P
T
T
H
T
E
E
Y
S
G
E
E
Dog
Lupus familis
XP_537366
637
72639
T176
E
N
A
P
S
T
H
T
E
E
Y
S
G
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIG8
637
72661
T176
A
N
A
P
T
T
H
T
E
E
Y
S
G
E
E
Rat
Rattus norvegicus
NP_001102337
637
72676
T176
E
N
A
P
T
A
H
T
E
E
Y
S
G
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084480
633
72267
E172
N
E
P
I
S
L
S
E
E
D
N
S
G
E
E
Zebra Danio
Brachydanio rerio
NP_001007184
631
71873
M172
E
N
E
P
S
K
Q
M
D
D
G
S
N
D
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9U6Y9
610
69722
E157
R
K
D
A
T
A
E
E
V
A
E
A
E
S
N
Honey Bee
Apis mellifera
XP_394141
622
71088
E163
K
Q
A
Y
S
Y
R
E
K
E
C
S
M
V
E
Nematode Worm
Caenorhab. elegans
P46580
734
83274
H213
Y
D
A
F
T
I
E
H
V
D
L
W
T
I
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002324705
645
72400
D165
K
T
D
D
D
A
M
D
A
N
S
T
S
F
I
Maize
Zea mays
NP_001141438
651
72748
N170
D
L
D
K
I
K
N
N
N
H
T
S
E
I
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GWT4
642
71852
D169
K
S
E
G
D
S
M
D
D
T
S
E
G
L
N
Baker's Yeast
Sacchar. cerevisiae
P38274
827
95135
L182
T
I
S
I
S
L
P
L
Y
E
D
S
D
P
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.4
98.9
99.3
N.A.
97.8
97.8
N.A.
N.A.
N.A.
83.6
78.6
N.A.
39.2
52.7
32.8
N.A.
Protein Similarity:
100
94.1
98.9
99.8
N.A.
99
99
N.A.
N.A.
N.A.
93
87.5
N.A.
56.6
69.2
49.7
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
N.A.
33.3
33.3
N.A.
6.6
26.6
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
N.A.
46.6
60
N.A.
13.3
46.6
26.6
N.A.
Percent
Protein Identity:
46.3
47.7
N.A.
46.8
22.8
N.A.
Protein Similarity:
63.8
63.2
N.A.
64.9
40.6
N.A.
P-Site Identity:
0
6.6
N.A.
6.6
13.3
N.A.
P-Site Similarity:
13.3
20
N.A.
33.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
54
7
0
20
0
0
7
7
0
7
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
7
7
20
7
14
0
0
14
14
20
7
0
7
7
0
% D
% Glu:
40
7
14
0
0
0
14
20
47
54
7
7
14
47
60
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
0
0
7
0
0
0
0
0
0
7
0
54
0
0
% G
% His:
0
0
0
0
0
0
40
7
0
7
0
0
0
0
0
% H
% Ile:
0
7
0
14
7
7
0
0
0
0
0
0
0
14
7
% I
% Lys:
20
7
0
7
0
14
0
0
7
0
0
0
0
0
0
% K
% Leu:
0
7
0
0
0
14
0
7
0
0
7
0
0
7
7
% L
% Met:
0
0
0
0
0
0
14
7
0
0
0
0
7
0
0
% M
% Asn:
7
47
0
0
0
0
7
7
7
7
7
0
7
0
14
% N
% Pro:
0
0
7
47
0
0
7
0
0
0
0
0
0
7
0
% P
% Gln:
0
7
0
0
0
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% R
% Ser:
0
7
7
0
34
7
7
0
0
0
14
74
7
7
0
% S
% Thr:
7
7
0
0
47
34
0
40
0
7
7
7
7
0
0
% T
% Val:
0
0
0
0
0
0
0
0
14
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
7
% W
% Tyr:
7
0
0
7
0
7
0
0
7
0
40
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _