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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRMT5
All Species:
33.03
Human Site:
T414
Identified Species:
51.9
UniProt:
O14744
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14744
NP_001034708.1
637
72684
T414
E
E
W
G
S
Q
V
T
V
V
S
S
D
M
R
Chimpanzee
Pan troglodytes
XP_509844
617
70208
E402
P
N
A
V
V
T
L
E
N
W
Q
F
E
E
W
Rhesus Macaque
Macaca mulatta
XP_001103964
644
73482
T421
E
E
W
G
S
Q
V
T
V
V
S
S
D
M
R
Dog
Lupus familis
XP_537366
637
72639
T414
E
E
W
G
S
Q
V
T
V
V
S
S
D
M
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIG8
637
72661
T414
E
E
W
G
S
Q
V
T
V
V
S
S
D
M
R
Rat
Rattus norvegicus
NP_001102337
637
72676
T414
E
E
W
G
S
Q
V
T
V
V
S
S
D
M
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084480
633
72267
T410
E
E
W
G
S
Q
V
T
V
V
S
G
D
M
R
Zebra Danio
Brachydanio rerio
NP_001007184
631
71873
T410
E
E
W
G
D
Q
V
T
V
V
S
C
D
M
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9U6Y9
610
69722
V390
T
L
W
A
D
K
D
V
H
I
F
S
K
D
M
Honey Bee
Apis mellifera
XP_394141
622
71088
T399
D
L
W
E
N
K
V
T
V
V
S
C
D
M
R
Nematode Worm
Caenorhab. elegans
P46580
734
83274
T472
R
T
W
K
R
R
V
T
I
I
E
S
D
M
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002324705
645
72400
V423
L
E
G
W
E
D
I
V
T
I
I
S
C
D
M
Maize
Zea mays
NP_001141438
651
72748
V429
L
E
G
W
E
S
L
V
T
V
I
S
S
D
M
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GWT4
642
71852
V420
M
E
G
W
E
D
V
V
T
I
I
S
C
D
M
Baker's Yeast
Sacchar. cerevisiae
P38274
827
95135
K436
D
C
W
D
N
R
V
K
L
I
K
E
D
M
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.4
98.9
99.3
N.A.
97.8
97.8
N.A.
N.A.
N.A.
83.6
78.6
N.A.
39.2
52.7
32.8
N.A.
Protein Similarity:
100
94.1
98.9
99.8
N.A.
99
99
N.A.
N.A.
N.A.
93
87.5
N.A.
56.6
69.2
49.7
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
86.6
N.A.
13.3
60
46.6
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
86.6
N.A.
26.6
80
66.6
N.A.
Percent
Protein Identity:
46.3
47.7
N.A.
46.8
22.8
N.A.
Protein Similarity:
63.8
63.2
N.A.
64.9
40.6
N.A.
P-Site Identity:
13.3
20
N.A.
20
26.6
N.A.
P-Site Similarity:
26.6
26.6
N.A.
26.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
14
14
0
0
% C
% Asp:
14
0
0
7
14
14
7
0
0
0
0
0
67
27
0
% D
% Glu:
47
67
0
7
20
0
0
7
0
0
7
7
7
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
7
7
0
0
0
% F
% Gly:
0
0
20
47
0
0
0
0
0
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
7
34
20
0
0
0
0
% I
% Lys:
0
0
0
7
0
14
0
7
0
0
7
0
7
0
0
% K
% Leu:
14
14
0
0
0
0
14
0
7
0
0
0
0
0
0
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
67
27
% M
% Asn:
0
7
0
0
14
0
0
0
7
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
47
0
0
0
0
7
0
0
0
0
% Q
% Arg:
7
0
0
0
7
14
0
0
0
0
0
0
0
0
60
% R
% Ser:
0
0
0
0
40
7
0
0
0
0
54
67
7
0
0
% S
% Thr:
7
7
0
0
0
7
0
60
20
0
0
0
0
0
7
% T
% Val:
0
0
0
7
7
0
74
27
54
60
0
0
0
0
0
% V
% Trp:
0
0
74
20
0
0
0
0
0
7
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _