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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRMT5 All Species: 25.15
Human Site: T520 Identified Species: 39.52
UniProt: O14744 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14744 NP_001034708.1 637 72684 T520 S A P Q P C F T F S H P N R D
Chimpanzee Pan troglodytes XP_509844 617 70208 P501 P E A Q F E M P Y V V R L H N
Rhesus Macaque Macaca mulatta XP_001103964 644 73482 T527 S A P Q P C F T F S H P N R D
Dog Lupus familis XP_537366 637 72639 T520 S A P Q P C F T F S H P N R D
Cat Felis silvestris
Mouse Mus musculus Q8CIG8 637 72661 T520 S A P K P C F T F S H P N R D
Rat Rattus norvegicus NP_001102337 637 72676 T520 S A P Q P C F T F S H P N R D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001084480 633 72267 T516 S D P L P C F T F H H P N K D
Zebra Danio Brachydanio rerio NP_001007184 631 71873 C514 Q L A D P Q A C F T F V H P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9U6Y9 610 69722 E493 D E P Q A L F E F V H P N R A
Honey Bee Apis mellifera XP_394141 622 71088 T505 A K P Q P L F T F N H P N N A
Nematode Worm Caenorhab. elegans P46580 734 83274 F611 A E T T K P V F T F E H P N F
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002324705 645 72400 H528 Q P V F T F T H P D Y S N K K
Maize Zea mays NP_001141438 651 72748 H534 Q Q V F T F T H P N F S P N A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8GWT4 642 71852 H525 Q S V F T F T H P N F S T K V
Baker's Yeast Sacchar. cerevisiae P38274 827 95135 G578 E F K I K H R G E I H G F I G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.4 98.9 99.3 N.A. 97.8 97.8 N.A. N.A. N.A. 83.6 78.6 N.A. 39.2 52.7 32.8 N.A.
Protein Similarity: 100 94.1 98.9 99.8 N.A. 99 99 N.A. N.A. N.A. 93 87.5 N.A. 56.6 69.2 49.7 N.A.
P-Site Identity: 100 6.6 100 100 N.A. 93.3 100 N.A. N.A. N.A. 73.3 13.3 N.A. 53.3 60 0 N.A.
P-Site Similarity: 100 20 100 100 N.A. 100 100 N.A. N.A. N.A. 80 26.6 N.A. 53.3 73.3 6.6 N.A.
Percent
Protein Identity: 46.3 47.7 N.A. 46.8 22.8 N.A.
Protein Similarity: 63.8 63.2 N.A. 64.9 40.6 N.A.
P-Site Identity: 6.6 0 N.A. 0 6.6 N.A.
P-Site Similarity: 20 6.6 N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 34 14 0 7 0 7 0 0 0 0 0 0 0 20 % A
% Cys: 0 0 0 0 0 40 0 7 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 7 0 0 0 0 0 7 0 0 0 0 40 % D
% Glu: 7 20 0 0 0 7 0 7 7 0 7 0 0 0 0 % E
% Phe: 0 7 0 20 7 20 54 7 60 7 20 0 7 0 7 % F
% Gly: 0 0 0 0 0 0 0 7 0 0 0 7 0 0 7 % G
% His: 0 0 0 0 0 7 0 20 0 7 60 7 7 7 0 % H
% Ile: 0 0 0 7 0 0 0 0 0 7 0 0 0 7 0 % I
% Lys: 0 7 7 7 14 0 0 0 0 0 0 0 0 20 7 % K
% Leu: 0 7 0 7 0 14 0 0 0 0 0 0 7 0 0 % L
% Met: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 20 0 0 60 20 7 % N
% Pro: 7 7 54 0 54 7 0 7 20 0 0 54 14 7 0 % P
% Gln: 27 7 0 47 0 7 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 7 0 0 0 0 7 0 40 0 % R
% Ser: 40 7 0 0 0 0 0 0 0 34 0 20 0 0 0 % S
% Thr: 0 0 7 7 20 0 20 47 7 7 0 0 7 0 7 % T
% Val: 0 0 20 0 0 0 7 0 0 14 7 7 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 7 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _