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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRMT5 All Species: 36.36
Human Site: Y280 Identified Species: 57.14
UniProt: O14744 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14744 NP_001034708.1 637 72684 Y280 S E K E F C S Y L Q Y L E Y L
Chimpanzee Pan troglodytes XP_509844 617 70208 H272 I I T G T N H H S E K E F C S
Rhesus Macaque Macaca mulatta XP_001103964 644 73482 Y287 S E K E F C S Y L Q Y L E Y L
Dog Lupus familis XP_537366 637 72639 Y280 S E K E F C S Y L Q Y L E Y L
Cat Felis silvestris
Mouse Mus musculus Q8CIG8 637 72661 Y280 S E K E F C S Y L Q Y L E Y L
Rat Rattus norvegicus NP_001102337 637 72676 Y280 S E K E F C S Y L Q Y L E Y L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001084480 633 72267 Y276 S E K D L C S Y L Q Y L E Y L
Zebra Danio Brachydanio rerio NP_001007184 631 71873 Y276 S E K D L R S Y L Q Y L E Y L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9U6Y9 610 69722 A256 S T N P N D K A L C Q Y A D Y
Honey Bee Apis mellifera XP_394141 622 71088 Y265 R Y Q S I T Y Y H N Y L E Y L
Nematode Worm Caenorhab. elegans P46580 734 83274 V332 L R H A V R N V N Y R S R P D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002324705 645 72400 Y290 Q R H S L R P Y L D Y V G F L
Maize Zea mays NP_001141438 651 72748 Y295 V R H A L A P Y L E Y I A Y L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8GWT4 642 71852 Y286 E K N P L R I Y L D Y V A Y L
Baker's Yeast Sacchar. cerevisiae P38274 827 95135 Y301 G E S A Y L E Y I N Y L L K K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.4 98.9 99.3 N.A. 97.8 97.8 N.A. N.A. N.A. 83.6 78.6 N.A. 39.2 52.7 32.8 N.A.
Protein Similarity: 100 94.1 98.9 99.8 N.A. 99 99 N.A. N.A. N.A. 93 87.5 N.A. 56.6 69.2 49.7 N.A.
P-Site Identity: 100 0 100 100 N.A. 100 100 N.A. N.A. N.A. 86.6 80 N.A. 13.3 40 0 N.A.
P-Site Similarity: 100 13.3 100 100 N.A. 100 100 N.A. N.A. N.A. 93.3 86.6 N.A. 13.3 46.6 6.6 N.A.
Percent
Protein Identity: 46.3 47.7 N.A. 46.8 22.8 N.A.
Protein Similarity: 63.8 63.2 N.A. 64.9 40.6 N.A.
P-Site Identity: 26.6 33.3 N.A. 33.3 26.6 N.A.
P-Site Similarity: 40 46.6 N.A. 46.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 20 0 7 0 7 0 0 0 0 20 0 0 % A
% Cys: 0 0 0 0 0 40 0 0 0 7 0 0 0 7 0 % C
% Asp: 0 0 0 14 0 7 0 0 0 14 0 0 0 7 7 % D
% Glu: 7 54 0 34 0 0 7 0 0 14 0 7 54 0 0 % E
% Phe: 0 0 0 0 34 0 0 0 0 0 0 0 7 7 0 % F
% Gly: 7 0 0 7 0 0 0 0 0 0 0 0 7 0 0 % G
% His: 0 0 20 0 0 0 7 7 7 0 0 0 0 0 0 % H
% Ile: 7 7 0 0 7 0 7 0 7 0 0 7 0 0 0 % I
% Lys: 0 7 47 0 0 0 7 0 0 0 7 0 0 7 7 % K
% Leu: 7 0 0 0 34 7 0 0 74 0 0 60 7 0 74 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 14 0 7 7 7 0 7 14 0 0 0 0 0 % N
% Pro: 0 0 0 14 0 0 14 0 0 0 0 0 0 7 0 % P
% Gln: 7 0 7 0 0 0 0 0 0 47 7 0 0 0 0 % Q
% Arg: 7 20 0 0 0 27 0 0 0 0 7 0 7 0 0 % R
% Ser: 54 0 7 14 0 0 47 0 7 0 0 7 0 0 7 % S
% Thr: 0 7 7 0 7 7 0 0 0 0 0 0 0 0 0 % T
% Val: 7 0 0 0 7 0 0 7 0 0 0 14 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 7 0 7 80 0 7 80 7 0 67 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _