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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRMT5
All Species:
42.73
Human Site:
Y481
Identified Species:
67.14
UniProt:
O14744
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14744
NP_001034708.1
637
72684
Y481
P
I
S
S
S
K
L
Y
N
E
V
R
A
C
R
Chimpanzee
Pan troglodytes
XP_509844
617
70208
Y468
G
V
S
I
P
G
E
Y
T
S
F
L
A
P
I
Rhesus Macaque
Macaca mulatta
XP_001103964
644
73482
Y488
P
I
S
S
S
K
L
Y
N
E
V
R
A
C
R
Dog
Lupus familis
XP_537366
637
72639
Y481
P
I
S
S
S
K
L
Y
N
E
V
R
A
C
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIG8
637
72661
Y481
P
I
S
S
S
K
L
Y
N
E
V
R
A
C
R
Rat
Rattus norvegicus
NP_001102337
637
72676
Y481
P
I
S
S
S
K
L
Y
N
E
V
R
A
C
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084480
633
72267
Y477
P
I
S
S
S
K
L
Y
N
E
V
R
A
C
R
Zebra Danio
Brachydanio rerio
NP_001007184
631
71873
Y477
P
L
S
S
S
K
L
Y
N
E
V
R
G
C
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9U6Y9
610
69722
H458
P
L
M
S
A
V
L
H
Q
N
V
C
Q
L
L
Honey Bee
Apis mellifera
XP_394141
622
71088
Y466
P
V
Q
S
S
K
L
Y
N
E
V
R
Q
C
R
Nematode Worm
Caenorhab. elegans
P46580
734
83274
H545
P
I
M
S
T
H
I
H
Q
T
I
K
A
Q
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002324705
645
72400
Y491
P
L
T
A
A
K
L
Y
N
D
V
K
S
H
K
Maize
Zea mays
NP_001141438
651
72748
H497
P
I
T
A
S
K
L
H
D
D
I
K
A
H
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GWT4
642
71852
Y488
P
I
T
A
S
K
L
Y
N
D
V
K
A
H
K
Baker's Yeast
Sacchar. cerevisiae
P38274
827
95135
Y510
P
I
S
S
P
L
F
Y
Q
K
L
S
Q
T
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.4
98.9
99.3
N.A.
97.8
97.8
N.A.
N.A.
N.A.
83.6
78.6
N.A.
39.2
52.7
32.8
N.A.
Protein Similarity:
100
94.1
98.9
99.8
N.A.
99
99
N.A.
N.A.
N.A.
93
87.5
N.A.
56.6
69.2
49.7
N.A.
P-Site Identity:
100
20
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
86.6
N.A.
26.6
80
26.6
N.A.
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
93.3
N.A.
46.6
86.6
60
N.A.
Percent
Protein Identity:
46.3
47.7
N.A.
46.8
22.8
N.A.
Protein Similarity:
63.8
63.2
N.A.
64.9
40.6
N.A.
P-Site Identity:
40
40
N.A.
60
33.3
N.A.
P-Site Similarity:
93.3
93.3
N.A.
93.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
20
14
0
0
0
0
0
0
0
67
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
54
0
% C
% Asp:
0
0
0
0
0
0
0
0
7
20
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
7
0
0
54
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
7
0
0
0
7
0
0
0
0
% F
% Gly:
7
0
0
0
0
7
0
0
0
0
0
0
7
0
0
% G
% His:
0
0
0
0
0
7
0
20
0
0
0
0
0
20
0
% H
% Ile:
0
67
0
7
0
0
7
0
0
0
14
0
0
0
7
% I
% Lys:
0
0
0
0
0
74
0
0
0
7
0
27
0
0
20
% K
% Leu:
0
20
0
0
0
7
80
0
0
0
7
7
0
7
7
% L
% Met:
0
0
14
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
67
7
0
0
0
0
7
% N
% Pro:
94
0
0
0
14
0
0
0
0
0
0
0
0
7
0
% P
% Gln:
0
0
7
0
0
0
0
0
20
0
0
0
20
7
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
54
0
0
54
% R
% Ser:
0
0
60
74
67
0
0
0
0
7
0
7
7
0
7
% S
% Thr:
0
0
20
0
7
0
0
0
7
7
0
0
0
7
0
% T
% Val:
0
14
0
0
0
7
0
0
0
0
74
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
80
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _