Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRMT5 All Species: 30
Human Site: Y535 Identified Species: 47.14
UniProt: O14744 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14744 NP_001034708.1 637 72684 Y535 P M I D N N R Y C T L E F P V
Chimpanzee Pan troglodytes XP_509844 617 70208 Q516 F H Q L S A P Q P C F T F S H
Rhesus Macaque Macaca mulatta XP_001103964 644 73482 Y542 P M I D N N R Y C T L E F P V
Dog Lupus familis XP_537366 637 72639 Y535 P M I D N N R Y C T L E F P V
Cat Felis silvestris
Mouse Mus musculus Q8CIG8 637 72661 Y535 P M I D N N R Y C T L E F P V
Rat Rattus norvegicus NP_001102337 637 72676 Y535 P M I D N N R Y C T L E F P V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001084480 633 72267 Y531 D V I D N N R Y C C L Q Y R V
Zebra Danio Brachydanio rerio NP_001007184 631 71873 Y529 T D M N N N R Y Q C L R F P V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9U6Y9 610 69722 C508 E N I D N T R C K T V S F K V
Honey Bee Apis mellifera XP_394141 622 71088 Y520 S V I D N S R Y D T K I F K V
Nematode Worm Caenorhab. elegans P46580 734 83274 S626 M N S S N E R S D S I E F V M
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002324705 645 72400 L543 S N Q R Y K R L Q F E I P S D
Maize Zea mays NP_001141438 651 72748 L549 S N Q R Y T K L Q F E M L P D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8GWT4 642 71852 L540 N N Q R Y K K L Q F S L P S D
Baker's Yeast Sacchar. cerevisiae P38274 827 95135 N593 F F S A N L Y N N I F L S T L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.4 98.9 99.3 N.A. 97.8 97.8 N.A. N.A. N.A. 83.6 78.6 N.A. 39.2 52.7 32.8 N.A.
Protein Similarity: 100 94.1 98.9 99.8 N.A. 99 99 N.A. N.A. N.A. 93 87.5 N.A. 56.6 69.2 49.7 N.A.
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. N.A. N.A. 60 53.3 N.A. 46.6 53.3 26.6 N.A.
P-Site Similarity: 100 13.3 100 100 N.A. 100 100 N.A. N.A. N.A. 80 66.6 N.A. 53.3 66.6 46.6 N.A.
Percent
Protein Identity: 46.3 47.7 N.A. 46.8 22.8 N.A.
Protein Similarity: 63.8 63.2 N.A. 64.9 40.6 N.A.
P-Site Identity: 6.6 6.6 N.A. 0 6.6 N.A.
P-Site Similarity: 6.6 13.3 N.A. 6.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 7 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 7 40 20 0 0 0 0 0 % C
% Asp: 7 7 0 54 0 0 0 0 14 0 0 0 0 0 20 % D
% Glu: 7 0 0 0 0 7 0 0 0 0 14 40 0 0 0 % E
% Phe: 14 7 0 0 0 0 0 0 0 20 14 0 67 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 7 % H
% Ile: 0 0 54 0 0 0 0 0 0 7 7 14 0 0 0 % I
% Lys: 0 0 0 0 0 14 14 0 7 0 7 0 0 14 0 % K
% Leu: 0 0 0 7 0 7 0 20 0 0 47 14 7 0 7 % L
% Met: 7 34 7 0 0 0 0 0 0 0 0 7 0 0 7 % M
% Asn: 7 34 0 7 74 47 0 7 7 0 0 0 0 0 0 % N
% Pro: 34 0 0 0 0 0 7 0 7 0 0 0 14 47 0 % P
% Gln: 0 0 27 0 0 0 0 7 27 0 0 7 0 0 0 % Q
% Arg: 0 0 0 20 0 0 74 0 0 0 0 7 0 7 0 % R
% Ser: 20 0 14 7 7 7 0 7 0 7 7 7 7 20 0 % S
% Thr: 7 0 0 0 0 14 0 0 0 47 0 7 0 7 0 % T
% Val: 0 14 0 0 0 0 0 0 0 0 7 0 0 7 60 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 20 0 7 54 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _