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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B6
All Species:
5.15
Human Site:
Y247
Identified Species:
11.33
UniProt:
O14756
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14756
NP_003716.2
317
35966
Y247
Q
Q
Y
F
D
A
L
Y
N
I
M
K
E
G
L
Chimpanzee
Pan troglodytes
Q1WNP0
328
34870
E258
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
Rhesus Macaque
Macaca mulatta
XP_001115423
317
35988
Y247
Q
Q
Y
F
D
A
F
Y
N
I
I
K
E
G
L
Dog
Lupus familis
XP_538239
317
36069
H247
Q
K
F
F
D
A
H
H
N
G
V
K
Q
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9R092
317
36084
C247
Q
Q
F
F
D
D
F
C
S
T
T
K
R
E
L
Rat
Rattus norvegicus
O54753
317
36126
C247
Q
Q
F
F
D
D
F
C
N
T
T
R
R
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJZ5
339
38218
R270
I
V
R
K
D
Y
G
R
K
Y
F
D
E
Q
V
Frog
Xenopus laevis
Q0IH28
323
35135
T252
K
N
T
A
D
G
R
T
P
E
E
V
A
Q
T
Zebra Danio
Brachydanio rerio
Q566S6
309
33329
G238
I
N
A
V
T
G
D
G
S
K
Y
G
V
M
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
S254
A
L
T
G
S
G
S
S
Y
G
K
V
D
E
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q05016
267
29140
P198
I
R
V
I
L
I
A
P
G
L
V
E
T
E
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
24.3
93
80.4
N.A.
73.1
70.9
N.A.
N.A.
32.1
22.6
26.1
N.A.
25.4
N.A.
N.A.
N.A.
Protein Similarity:
100
39.9
96.5
88
N.A.
82
82
N.A.
N.A.
54.2
44.5
46.3
N.A.
43.5
N.A.
N.A.
N.A.
P-Site Identity:
100
0
86.6
53.3
N.A.
40
40
N.A.
N.A.
13.3
6.6
0
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
93.3
86.6
N.A.
53.3
53.3
N.A.
N.A.
20
13.3
6.6
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
10
0
28
10
0
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
19
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
64
19
10
0
0
0
0
10
10
0
10
% D
% Glu:
0
0
0
0
0
0
0
10
0
10
10
10
28
37
0
% E
% Phe:
0
0
28
46
10
0
28
0
0
10
10
0
0
0
10
% F
% Gly:
0
0
0
10
0
28
10
10
10
19
0
10
0
28
0
% G
% His:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% H
% Ile:
28
0
0
10
0
10
0
0
0
19
10
0
0
0
0
% I
% Lys:
10
10
0
10
0
0
0
0
10
10
10
37
0
0
0
% K
% Leu:
0
19
0
0
10
0
10
0
0
10
10
0
10
10
46
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% M
% Asn:
0
19
0
0
0
0
0
0
37
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
10
10
0
0
10
0
0
0
% P
% Gln:
46
37
0
0
0
0
0
0
0
0
0
0
10
19
0
% Q
% Arg:
0
10
19
0
0
0
10
10
10
0
0
10
19
0
10
% R
% Ser:
0
0
0
0
10
0
10
10
19
0
0
0
0
0
0
% S
% Thr:
10
0
19
0
10
10
10
10
0
19
19
0
10
0
19
% T
% Val:
0
10
10
10
0
0
0
0
0
0
19
19
10
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
19
10
0
10
0
19
10
10
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _