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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MRAS All Species: 22.73
Human Site: Y42 Identified Species: 38.46
UniProt: O14807 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14807 NP_001078518.1 208 23846 Y42 Q K I F V P D Y D P T I E D S
Chimpanzee Pan troglodytes XP_001171965 204 23353 Y43 Q S Y F V T D Y D P T I E D S
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O08989 208 23883 Y42 Q K I F V P D Y D P T I E D S
Rat Rattus norvegicus P97538 208 23869 Y42 Q K I F V P D Y D P T I E D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507773 243 27878 A77 G N K G S G P A T V L A V S L
Chicken Gallus gallus NP_989820 208 23771 Y42 Q K I F V P D Y D P T I E D S
Frog Xenopus laevis Q7ZXH7 184 20815 S39 Y D P T I E D S Y R K Q V E V
Zebra Danio Brachydanio rerio Q6TEN1 184 20809 S39 Y D P T I E D S Y R K Q V E V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P04388 192 22217 Y42 D P T I E D S Y T K Q C N I D
Honey Bee Apis mellifera XP_393895 198 22919 D42 K L F V T D Y D P T I E D S Y
Nematode Worm Caenorhab. elegans NP_497972 211 24021 Y46 Q K Q F V D Y Y D P T I E D Q
Sea Urchin Strong. purpuratus XP_784862 177 19938 I32 V G K S A I T I Q F F Q K L F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P01119 309 34328 Q77 E Y S A M R E Q Y M R T G E G
Red Bread Mold Neurospora crassa P22126 213 24008 E42 D E Y D P T I E D S Y R K Q C
Conservation
Percent
Protein Identity: 100 55.2 N.A. N.A. N.A. 96.6 97.1 N.A. 62.9 97.5 46.1 45.6 N.A. 50 68.7 54 62.9
Protein Similarity: 100 70.1 N.A. N.A. N.A. 99.5 99.5 N.A. 69.5 99 63.4 63.4 N.A. 69.7 82.6 71 74
P-Site Identity: 100 80 N.A. N.A. N.A. 100 100 N.A. 0 100 6.6 6.6 N.A. 6.6 0 73.3 0
P-Site Similarity: 100 80 N.A. N.A. N.A. 100 100 N.A. 0 100 20 20 N.A. 6.6 13.3 73.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.6 49.7
Protein Similarity: N.A. N.A. N.A. N.A. 48.2 66.6
P-Site Identity: N.A. N.A. N.A. N.A. 0 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 8 0 0 8 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % C
% Asp: 15 15 0 8 0 22 50 8 50 0 0 0 8 43 8 % D
% Glu: 8 8 0 0 8 15 8 8 0 0 0 8 43 22 0 % E
% Phe: 0 0 8 43 0 0 0 0 0 8 8 0 0 0 8 % F
% Gly: 8 8 0 8 0 8 0 0 0 0 0 0 8 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 29 8 15 8 8 8 0 0 8 43 0 8 0 % I
% Lys: 8 36 15 0 0 0 0 0 0 8 15 0 15 0 0 % K
% Leu: 0 8 0 0 0 0 0 0 0 0 8 0 0 8 8 % L
% Met: 0 0 0 0 8 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % N
% Pro: 0 8 15 0 8 29 8 0 8 43 0 0 0 0 0 % P
% Gln: 43 0 8 0 0 0 0 8 8 0 8 22 0 8 8 % Q
% Arg: 0 0 0 0 0 8 0 0 0 15 8 8 0 0 0 % R
% Ser: 0 8 8 8 8 0 8 15 0 8 0 0 0 15 36 % S
% Thr: 0 0 8 15 8 15 8 0 15 8 43 8 0 0 0 % T
% Val: 8 0 0 8 43 0 0 0 0 8 0 0 22 0 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 15 8 15 0 0 0 15 50 22 0 8 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _