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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RASGRF2
All Species:
13.64
Human Site:
S749
Identified Species:
33.33
UniProt:
O14827
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14827
NP_008840.1
1237
140764
S749
A
R
K
L
S
L
T
S
P
L
N
S
K
I
G
Chimpanzee
Pan troglodytes
XP_517672
1237
140775
S749
A
R
K
L
S
L
T
S
P
L
N
S
K
I
G
Rhesus Macaque
Macaca mulatta
XP_001108408
514
59608
C73
Y
L
L
E
G
C
V
C
D
R
A
P
S
P
K
Dog
Lupus familis
XP_852734
1350
152162
S749
A
R
K
L
S
L
T
S
P
L
N
S
R
I
G
Cat
Felis silvestris
Mouse
Mus musculus
P70392
1189
135649
R734
P
P
P
L
A
V
S
R
T
S
S
P
V
R
A
Rat
Rattus norvegicus
Q99JE4
1190
135808
R734
P
P
P
L
A
V
S
R
T
S
S
P
V
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510010
1242
141041
S753
A
R
K
L
S
L
T
S
P
M
N
S
R
I
G
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A2CEA7
1244
141569
N745
R
T
R
K
L
S
L
N
S
P
I
G
S
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001122143
690
76494
H249
G
G
T
Q
V
I
V
H
L
V
A
P
T
I
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780300
1211
137984
N744
N
H
P
G
A
G
A
N
I
K
V
T
M
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
31.3
87.1
N.A.
91.1
91.2
N.A.
91.2
N.A.
N.A.
85.4
N.A.
N.A.
25.4
N.A.
48.5
Protein Similarity:
100
99.7
36.2
89.2
N.A.
93.5
93.6
N.A.
95.1
N.A.
N.A.
91.6
N.A.
N.A.
37
N.A.
64.7
P-Site Identity:
100
100
0
93.3
N.A.
6.6
6.6
N.A.
86.6
N.A.
N.A.
0
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
100
100
0
100
N.A.
33.3
33.3
N.A.
100
N.A.
N.A.
13.3
N.A.
N.A.
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
40
0
0
0
30
0
10
0
0
0
20
0
0
0
20
% A
% Cys:
0
0
0
0
0
10
0
10
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% D
% Glu:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
10
0
10
10
10
0
0
0
0
0
10
0
0
40
% G
% His:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
10
0
10
0
0
50
0
% I
% Lys:
0
0
40
10
0
0
0
0
0
10
0
0
20
10
20
% K
% Leu:
0
10
10
60
10
40
10
0
10
30
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% M
% Asn:
10
0
0
0
0
0
0
20
0
0
40
0
0
0
0
% N
% Pro:
20
20
30
0
0
0
0
0
40
10
0
40
0
10
0
% P
% Gln:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
10
40
10
0
0
0
0
20
0
10
0
0
20
20
0
% R
% Ser:
0
0
0
0
40
10
20
40
10
20
20
40
20
0
0
% S
% Thr:
0
10
10
0
0
0
40
0
20
0
0
10
10
10
0
% T
% Val:
0
0
0
0
10
20
20
0
0
10
10
0
20
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _