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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: OPLAH All Species: 23.64
Human Site: T543 Identified Species: 47.27
UniProt: O14841 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14841 NP_060040.1 1288 137457 T543 S L L Y A P E T F V Q L D Q R
Chimpanzee Pan troglodytes XP_528261 1212 130154 L520 H S G L L S A L G L A L A D V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539206 1379 147579 T640 S L P Y A P E T F V Q L D Q R
Cat Felis silvestris
Mouse Mus musculus Q8K010 1288 137593 T543 S L S Y T P E T F A Q L D Q R
Rat Rattus norvegicus P97608 1288 137702 T543 S L S Y T P E T F A Q L D Q R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521030 1300 139318 V554 S L P Y V A E V F P Q L D E R
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611675 1294 139594 N543 G L E F S D A N A Q Q L K E R
Honey Bee Apis mellifera XP_001121487 1287 139635 S544 A E V Y E Q E S F A R L D E R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_794494 1307 142838 A552 A D S Y E Q A A F K H I D E R
Poplar Tree Populus trichocarpa XP_002305860 1269 137853 S551 S A V Y G P D S I L E A S H R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FIZ7 1266 137512 S547 S A V Y G P E S L S E V F R R
Baker's Yeast Sacchar. cerevisiae P28273 1286 140409 T549 F I L G E P E T I L K V K K R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.5 N.A. 69.4 N.A. 92.5 93.9 N.A. 80.2 N.A. N.A. N.A. N.A. 61.2 65 N.A. 64.1
Protein Similarity: 100 93.1 N.A. 74 N.A. 95.6 96.1 N.A. 87.2 N.A. N.A. N.A. N.A. 74.5 76.9 N.A. 76.1
P-Site Identity: 100 6.6 N.A. 93.3 N.A. 80 80 N.A. 60 N.A. N.A. N.A. N.A. 26.6 40 N.A. 26.6
P-Site Similarity: 100 13.3 N.A. 93.3 N.A. 80 80 N.A. 66.6 N.A. N.A. N.A. N.A. 46.6 73.3 N.A. 46.6
Percent
Protein Identity: 57.2 N.A. N.A. 56.8 49 N.A.
Protein Similarity: 70.9 N.A. N.A. 71.2 66 N.A.
P-Site Identity: 26.6 N.A. N.A. 33.3 33.3 N.A.
P-Site Similarity: 60 N.A. N.A. 66.6 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 17 0 0 17 9 25 9 9 25 9 9 9 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 0 0 9 9 0 0 0 0 0 59 9 0 % D
% Glu: 0 9 9 0 25 0 67 0 0 0 17 0 0 34 0 % E
% Phe: 9 0 0 9 0 0 0 0 59 0 0 0 9 0 0 % F
% Gly: 9 0 9 9 17 0 0 0 9 0 0 0 0 0 0 % G
% His: 9 0 0 0 0 0 0 0 0 0 9 0 0 9 0 % H
% Ile: 0 9 0 0 0 0 0 0 17 0 0 9 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 9 9 0 17 9 0 % K
% Leu: 0 50 17 9 9 0 0 9 9 25 0 67 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % N
% Pro: 0 0 17 0 0 59 0 0 0 9 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 17 0 0 0 9 50 0 0 34 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 9 0 0 9 92 % R
% Ser: 59 9 25 0 9 9 0 25 0 9 0 0 9 0 0 % S
% Thr: 0 0 0 0 17 0 0 42 0 0 0 0 0 0 0 % T
% Val: 0 0 25 0 9 0 0 9 0 17 0 17 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 75 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _