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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: BCKDK All Species: 21.21
Human Site: S31 Identified Species: 33.33
UniProt: O14874 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14874 NP_001116429.1 412 46360 S31 A L A L R A R S T S A T D T H
Chimpanzee Pan troglodytes XP_001156184 412 46441 S31 A L A L R A R S T S A T D T H
Rhesus Macaque Macaca mulatta XP_001112186 412 46391 S31 T L A L R A R S T S A T D T H
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O55028 412 46569 S31 S L S L R A R S T S A T D T H
Rat Rattus norvegicus Q00972 412 46456 S31 S L S L R V R S T S A T D T H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511214 371 41647 L25 R G P L L L P L L S P A L R F
Chicken Gallus gallus
Frog Xenopus laevis NP_001085012 413 47032 S31 L L P I R S R S T S A T D H H
Zebra Danio Brachydanio rerio NP_998225 419 46906 R39 H G V G R R F R S T S S M S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91622 413 46608 L33 S G F N P S P L S I K Q F M D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q02332 401 45263 F25 K L D Y Y S Q F Q P S S L T I
Sea Urchin Strong. purpuratus XP_780213 418 46942 Q36 A I T S Y R P Q S N Y S A V H
Poplar Tree Populus trichocarpa XP_002314330 369 41691 G22 F E E V Q R W G C M K Q T G V
Maize Zea mays NP_001105608 364 41356 G18 A E E V G R W G S M K Q T G V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_187300 366 41428 K20 S L I E D V H K W G C M K Q T
Baker's Yeast Sacchar. cerevisiae P40530 394 45425 L26 Q R P S H E L L S Q L S F D Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98 N.A. N.A. 95.1 95.6 N.A. 73.3 N.A. 82 75.8 N.A. 22.7 N.A. 24.5 61.2
Protein Similarity: 100 99.7 98.5 N.A. N.A. 96.8 96.5 N.A. 78.4 N.A. 89.8 84.4 N.A. 39.7 N.A. 42.4 74.8
P-Site Identity: 100 100 93.3 N.A. N.A. 86.6 80 N.A. 13.3 N.A. 66.6 6.6 N.A. 0 N.A. 13.3 13.3
P-Site Similarity: 100 100 93.3 N.A. N.A. 100 93.3 N.A. 13.3 N.A. 80 40 N.A. 20 N.A. 40 40
Percent
Protein Identity: 32.2 33.5 N.A. 31.8 25.7 N.A.
Protein Similarity: 51.7 53.1 N.A. 50.9 47.5 N.A.
P-Site Identity: 0 6.6 N.A. 6.6 0 N.A.
P-Site Similarity: 13.3 20 N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 27 0 20 0 0 27 0 0 0 0 40 7 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 7 0 7 0 0 0 0 % C
% Asp: 0 0 7 0 7 0 0 0 0 0 0 0 40 7 7 % D
% Glu: 0 14 14 7 0 7 0 0 0 0 0 0 0 0 0 % E
% Phe: 7 0 7 0 0 0 7 7 0 0 0 0 14 0 7 % F
% Gly: 0 20 0 7 7 0 0 14 0 7 0 0 0 14 0 % G
% His: 7 0 0 0 7 0 7 0 0 0 0 0 0 7 47 % H
% Ile: 0 7 7 7 0 0 0 0 0 7 0 0 0 0 7 % I
% Lys: 7 0 0 0 0 0 0 7 0 0 20 0 7 0 0 % K
% Leu: 7 54 0 40 7 7 7 20 7 0 7 0 14 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 14 0 7 7 7 0 % M
% Asn: 0 0 0 7 0 0 0 0 0 7 0 0 0 0 0 % N
% Pro: 0 0 20 0 7 0 20 0 0 7 7 0 0 0 0 % P
% Gln: 7 0 0 0 7 0 7 7 7 7 0 20 0 7 7 % Q
% Arg: 7 7 0 0 47 27 40 7 0 0 0 0 0 7 0 % R
% Ser: 27 0 14 14 0 20 0 40 34 47 14 27 0 7 7 % S
% Thr: 7 0 7 0 0 0 0 0 40 7 0 40 14 40 7 % T
% Val: 0 0 7 14 0 14 0 0 0 0 0 0 0 7 14 % V
% Trp: 0 0 0 0 0 0 14 0 7 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 14 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _