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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: BCKDK All Species: 24.24
Human Site: S33 Identified Species: 38.1
UniProt: O14874 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14874 NP_001116429.1 412 46360 S33 A L R A R S T S A T D T H H V
Chimpanzee Pan troglodytes XP_001156184 412 46441 S33 A L R A R S T S A T D T H H V
Rhesus Macaque Macaca mulatta XP_001112186 412 46391 S33 A L R A R S T S A T D T H H V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O55028 412 46569 S33 S L R A R S T S A T D T H H V
Rat Rattus norvegicus Q00972 412 46456 S33 S L R V R S T S A T D T H H V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511214 371 41647 S27 P L L L P L L S P A L R F R S
Chicken Gallus gallus
Frog Xenopus laevis NP_001085012 413 47032 S33 P I R S R S T S A T D H H H T
Zebra Danio Brachydanio rerio NP_998225 419 46906 T41 V G R R F R S T S S M S S Y S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91622 413 46608 I35 F N P S P L S I K Q F M D F G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q02332 401 45263 P27 D Y Y S Q F Q P S S L T I Q Q
Sea Urchin Strong. purpuratus XP_780213 418 46942 N38 T S Y R P Q S N Y S A V H D Y
Poplar Tree Populus trichocarpa XP_002314330 369 41691 M24 E V Q R W G C M K Q T G V S L
Maize Zea mays NP_001105608 364 41356 M20 E V G R W G S M K Q T G V T L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_187300 366 41428 G22 I E D V H K W G C M K Q T G V
Baker's Yeast Sacchar. cerevisiae P40530 394 45425 Q28 P S H E L L S Q L S F D Q H Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98 N.A. N.A. 95.1 95.6 N.A. 73.3 N.A. 82 75.8 N.A. 22.7 N.A. 24.5 61.2
Protein Similarity: 100 99.7 98.5 N.A. N.A. 96.8 96.5 N.A. 78.4 N.A. 89.8 84.4 N.A. 39.7 N.A. 42.4 74.8
P-Site Identity: 100 100 100 N.A. N.A. 93.3 86.6 N.A. 13.3 N.A. 66.6 6.6 N.A. 0 N.A. 6.6 6.6
P-Site Similarity: 100 100 100 N.A. N.A. 100 93.3 N.A. 13.3 N.A. 80 46.6 N.A. 13.3 N.A. 33.3 26.6
Percent
Protein Identity: 32.2 33.5 N.A. 31.8 25.7 N.A.
Protein Similarity: 51.7 53.1 N.A. 50.9 47.5 N.A.
P-Site Identity: 0 0 N.A. 6.6 6.6 N.A.
P-Site Similarity: 20 20 N.A. 6.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 0 0 27 0 0 0 0 40 7 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 7 0 7 0 0 0 0 0 0 % C
% Asp: 7 0 7 0 0 0 0 0 0 0 40 7 7 7 0 % D
% Glu: 14 7 0 7 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 7 0 0 0 7 7 0 0 0 0 14 0 7 7 0 % F
% Gly: 0 7 7 0 0 14 0 7 0 0 0 14 0 7 7 % G
% His: 0 0 7 0 7 0 0 0 0 0 0 7 47 47 0 % H
% Ile: 7 7 0 0 0 0 0 7 0 0 0 0 7 0 0 % I
% Lys: 0 0 0 0 0 7 0 0 20 0 7 0 0 0 0 % K
% Leu: 0 40 7 7 7 20 7 0 7 0 14 0 0 0 14 % L
% Met: 0 0 0 0 0 0 0 14 0 7 7 7 0 0 0 % M
% Asn: 0 7 0 0 0 0 0 7 0 0 0 0 0 0 0 % N
% Pro: 20 0 7 0 20 0 0 7 7 0 0 0 0 0 0 % P
% Gln: 0 0 7 0 7 7 7 7 0 20 0 7 7 7 7 % Q
% Arg: 0 0 47 27 40 7 0 0 0 0 0 7 0 7 0 % R
% Ser: 14 14 0 20 0 40 34 47 14 27 0 7 7 7 14 % S
% Thr: 7 0 0 0 0 0 40 7 0 40 14 40 7 7 7 % T
% Val: 7 14 0 14 0 0 0 0 0 0 0 7 14 0 40 % V
% Trp: 0 0 0 0 14 0 7 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 14 0 0 0 0 0 7 0 0 0 0 7 14 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _